| 归芍清血合剂质量标准研究 |
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| 引用本文： | 胡静.归芍清血合剂质量标准研究[J].环球中医药,2010,3(1):53-55. |
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| 作者姓名： | 胡静 |
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| 作者单位： | 湖北省荆州市中心医院/华中科技大学同济医学院附属荆州医院药剂科,434020 |
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| 摘 要： | 目的制订归芍清血合剂质量控制方法。方法采用薄层色谱法对方中赤芍、当归、金银花、黄芩进行定性研究,采用高效液相色谱法,以乙腈-水(20:80)为流动相,检测波长230 nm,采用C18柱(4.6 mm×250 mm,5μm),测定方赤芍中芍药苷的含量。结果赤芍、当归、金银花、黄芩可用薄层色谱鉴别,芍药苷在0.04～0.48μg范围内线性关系良好(r=0.9994),平均回收率为97.13%,RSD为1.18%(n=6)。结论所建立的质量标准方法简便、快捷,重现性好,可用于归芍清血合剂的质量控制。
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| 关 键 词： | 归芍清血合剂 质量控制 芍药苷 |
Study On quality standard of Guishaoqingxue-Mixture |
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| HU Jing.Study On quality standard of Guishaoqingxue-Mixture[J].Global Chinese Medicine,2010,3(1):53-55. |
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| Authors: | HU Jing |
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| Affiliation: | HU jing. (ringzhou City Central Hospital Pharmacy( The Affliated Jingzhou Hospital to Tong/i Medical College of Huazhong University of Science Technology) , Hubei ringzhou 434020, China) |
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| Abstract: | Objective To establish the method for quality control of Guishao qingxue-Mixture. Methods Paeoniflorin, ferulic acid, chlorogenic acid and baicalin in Guishaoqingxue-Mixture were identified by TLC, Paeoniflorin was determined by HPLC. The condition of HPLC was Eclipse XDB-C18 column, acetonitrile-water（20： 80） as mobile phase; the detection wavelength was 230nm. Results Paeoniflorin, ferulic acid, chlorogenic acid and baicalin can be identified by TLC ; The calibration cure was linear in the range of 0.04 -0. 48 μg（ r = 0. 9994 ） for paeoniflorin. The average recovery was 97. 13% , RSD was 1. 18% （n = 6）. Conclusion The method is simple, accurate and suitable for the quality control of Guishaoqingxue-Mixture. |
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| Keywords: | HPLC Guishaoqingxue-mixture Paeoniflorin |
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