中药痛痹颗粒治疗骨关节炎的实验研究

目的:观察痛痹颗粒对大鼠自由基代谢及血液流变性的影响,探讨痛痹颗粒治疗骨关节炎的可能机制。方法:采用16月龄SD大鼠,连续给予痛痹颗粒45天,末次给药后取血清测SOD、MDA含量。采用皮下注入肾上腺素加冰水复制血瘀模型,测定全血黏度、血浆黏度、红细胞聚集指数,刚性指数等指标。结果:痛痹颗粒明显提高老龄大鼠血清中SOD活性,降低MDA含量,与老龄组比较具有显著性差异(P0.01)。对血瘀大鼠可明显降低全血黏度值、血浆黏度值、红细胞聚集指数和红细胞刚性指数,与模型组比较具有显著性差异(P0.01)。结论:痛痹颗粒治疗骨关节炎的作用机制可能与改善机体血液流变性,清除氧自由基和抗衰老作用有关。

Experimental Research on Effect of Tongbi Granules Treating Osteoarthritis

Objective:Observation of free radical metabolism and hemorheology in rats given Tongbi granules was made.Exploration on the mechanism of Tongbi granules treating osteoarthritis was made.Methods:16-month-old SD rats were given Tongbi granules consecutively for 45d,then the serum SOD and MDA were measured after the last administration.Epinephrine subcutaneous and ice water were used to duplicate blood stasis model,then the whole blood viscosity,plasma viscosity,erythrocyte aggregation index and rigidity index were detected.Results:Tongbi granules significantly increased serum SOD activity and lower MDA contentin aged rats,compared with aging group there was a significant difference(P<0.01).Tongbi granules can significantly reduce blood stasis model whole blood viscosity,plasma viscosity,erythrocyte aggregation and erythrocyte rigidity index,compared with model group there was a significant difference(P<0.01).Conclusion:The mechanism of Tongbi granules treating osteoarthritis may be associated with improving hemorheology,scavenging oxygen free radicals and anti-aging.