| 黄芪当归配伍对气道变应性炎症大鼠鼻黏膜及肺组织GATA-3、T-bet表达的影响 |
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| 引用本文： | 袁颖,符胜光,郭忻.黄芪当归配伍对气道变应性炎症大鼠鼻黏膜及肺组织GATA-3、T-bet表达的影响[J].中华中医药学刊,2011(7):1661-1663. |
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| 作者姓名： | 袁颖 符胜光 郭忻 |
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| 作者单位： | 上海中医药大学; |
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| 摘 要： | 目的:通过研究黄芪当归配伍对气道变应性炎症模型大鼠鼻黏膜及肺组织GATA-3、T-bet表达的影响,探讨黄芪当归配伍治疗气道变应性炎症的作用机制。方法:采用卵清蛋白(OVA)喷雾的方法致敏造成大鼠气道变应性炎症模型,分别用黄芪、当归、黄芪当归配伍灌胃给药治疗。用免疫组化法测定鼻黏膜中及肺组织中GATA-3、T-bet的表达。结果:模型组鼻黏膜及肺组织GATA-3表达增加,而T-bet表达降低。当归组可降低肺组织GATA-3表达,增加鼻黏膜T-bet的表达;黄芪组可降低肺组织GATA-3表达,升高鼻黏膜及肺组织T-bet表达;芪归组可降低鼻黏膜及肺组织GATA-3表达,升高鼻黏膜和肺组织T-bet表达。各给药组均可降低鼻黏膜及肺组织中GATA-3/T-bet比值。结论:黄芪当归配伍可能通过对GATA-3/T-bet的影响,调节气道变应性炎症中Th1/Th2细胞因子平衡,从而对气道变应性炎症有抑制作用。
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| 关 键 词： | 黄芪 当归 气道变应性炎症 GATA-3 T-bet |
The Effect of HuangQi and DangGui on Levels of GATA-3 and T-bet in Nasal Mucosaand Lung Tissue of Airway Allergic Inflammation Rats |
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| YUAN Ying,FU Sheng-gang,GUO Xin.The Effect of HuangQi and DangGui on Levels of GATA-3 and T-bet in Nasal Mucosaand Lung Tissue of Airway Allergic Inflammation Rats[J].Chinese Archives of Traditional Chinese Medicine,2011(7):1661-1663. |
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| Authors: | YUAN Ying FU Sheng-gang GUO Xin |
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| Affiliation: | YUAN Ying,FU Sheng-gang,GUO Xin (Shanghai University of TCM,Shanghai 201203,China) |
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| Abstract: | Objective:To observe the Influence of HuangQi and DangGui on levels of GATA-3 and T-bet in nasal mucosa and lung tissue of airway allergic inflammation rats,in order to partly show the mechanism of HuangQi and DangGui treating airway allergic inflammation.Methods:Using the model of airway allergic inflammation rats caused by OVA,we observed the effect of HuangQi and DangGui on expression of GATA-3 and T-bet in nasal mucosa and lung tissue by immunohistochemical staining method.Results:The expression of GATA... |
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| Keywords: | HuangQi DangGui airway allergic inflammation GATA-3 T-bet |
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