| 灯盏花乙素清除活性氧作用的研究 |
| |
| 引用本文： | 刘宏,杨祥良,周林珠,徐辉碧.灯盏花乙素清除活性氧作用的研究[J].中药材,2002,25(7):491-493. |
| |
| 作者姓名： | 刘宏 杨祥良 周林珠 徐辉碧 |
| |
| 作者单位： | 华中科技大学药物研究所,武汉,430074 |
| |
| 摘 要： | 目的:研究灯盏花乙素体外清除活性氧的作用,探讨其作用机制。方法:采用化学发光法检测灯盏花乙素对邻菲罗啉-抗坏血酸体系产生的羟自由基、黄嘌呤-黄嘌呤氧化酶-鲁米诺体系产生的超氧阴离子及过氧化氢的清除作用。结果:灯盏花乙素具有清除羟自由基、超氧阴离子及过氧化氢的作用,其 IC_(50)分别为66 μg/ml、1.3 μg/ml和 1.6 μg/ml。结论:灯盏花乙素是一种有效的抗氧化剂。
|
| 关 键 词： | 灯盏花乙素 活性氧 化学发光 |
| 修稿时间： | 2002年1月22日 |
Study on Effects of Scutellsrin on Scavenging Reactive Oxygen |
| |
| Liu Hong,Yang Xiangliang,Zhou Linzhu,Xu Huibi.Study on Effects of Scutellsrin on Scavenging Reactive Oxygen[J].Jorunal of Chinese Medicinal Materials,2002,25(7):491-493. |
| |
| Authors: | Liu Hong Yang Xiangliang Zhou Linzhu Xu Huibi |
| |
| Affiliation: | Institute of Pharmacy, Huazhong University of Science & Technology, Wuhan 430074. |
| |
| Abstract: | Objective:To study the antioxidative effects and its mechanism of scutellsrin. Methods:Scavenging effects of Scutellsrin on hy-droxyl radical (OH-)produced from 0-phenathroline-ascorbic acid system, super oxide anion radical(O2)produced from xanthine-xanthine oxi-dase-luminol system and hydrogen peroxide was studied by a chemiluminescence assay.Results:Scutellsrin has a significant effect on scavenging hydroxyl radicals, super oxide anion radicals, hydrogen peroxide, their IC50 are 66ug/ml ,1.3ug/ml and 1.6ug/ml respectively. Conclusion: Scutellsrin is an efficiency antioxidant. |
| |
| Keywords: | Scutellsrin Reactive oxygen Chemiluminescence |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
