EFFECT OF ELECTROACUPUNCTURE ON CANINE PYLORIC PRESSURE AND ITS RELATION TO SOMATOSTATIN AND NITRIC OXIDE

Inrecentyears,studiesdemonstratethatEAisofagoodrequlativeeffectonthegastroin-testinalmovement,butitsmechanismsremainunknown.SomeresearchersoncereportedthatEAcouldregulatepressureofthesphinctermus-cleofthegastricpylorusinhumanbody'],in-fluencingreleaseofsomeplasmabiryactivesub-.t.....2],however,itsexactmodulationlinksandtheirPossibleintrinsicconnectionofgas-trointestinalhormoneshavenotbeenunderstoodcompletely.Uptonow,therehavenotbeenanysimilarstudiesonEAforregulatingpyloricpres-sureanditsre…

EFFECT OF ELECTROACUPUNCTURE ON CANINE PYLORIC PRESSURE AND ITS RELATION TO SOMATOSTATIN AND NITRIC OXIDE

Purpose of the present study: To explore the effect of electroacupuncture (EA) on canine pyloric pressure and its relation to somatostain (SS) of blood plasma and nitric oxide (NO).Methods: An intragastric pressure detector and radioimmunoassay (RIA) and biochemical assay are used to determine changes of pyloric pressure and frequency, contents of SS and NO of blood plasma after EA stimulation of different acupoints. Results: Following EA of Zusanli (ST 36), the total pressure, basic pressure and systolic frequency of the sphincter muscle of pylorus lowered, plasma SS content decreased and NO content increased. After EA of Shangjuxu (ST 37), the total pressure, basic pressure and systolic frequency of the sphincter muscle of pylorus decreased, plasrna NO content increased but changes of these indexes are less obvious than those of EA of Zusanli (ST 36). These indexes in other groups had no any apparent changes. Conclusion: EA could lower pyloric pressure and systolic frequency of the pyloric sphincter muscle, whicb may be the important pathway of EA in regulating functional activities of the stomach and intestines. The effect of EA is associated with the contents of some plasma biological substances affecting pyloric pressure and the action of meridians and acupoints is of specificity to a certain degree.