瓜蒌薤白桂枝汤对老年冠心病患者的临床观察

目的:探究瓜蒌薤白桂枝汤对老年冠心病患者血脂及NT-proBNP、hs-CRP、Fib水平影响。方法:选取2014年4月至2018年4月西藏民族大学附属医院收治的老年冠心病患者78例作为研究对象,根据就诊顺序编号,按照随机数字表法随机分为对照组和观察组,每组39例。对照组常规西医治疗,观察组在对照组基础上加用瓜蒌薤白桂枝汤治疗,同时治疗4周。观察2组治疗前、完成治疗后血脂、NT-pro BNP、hs-CRP、Fib、WBC、HCY、血流流变学、心脏功能水平变化并比较;完成治疗后进行疗效评价。结果:观察组患者治疗后TC、TG、HDL-C、NT-proBNP、hs-CRP、Fib、WBC、HCY、全血高切黏度、全血低切黏度、血浆黏度、红细胞聚集指数下降较对照组患者幅度更低,LDL-C、EDD、NEDD、LVEF、LVPFR上升幅度及治疗后临床总有效率较对照组更高(P<0.05)。结论:瓜蒌薤白桂枝汤能降低老年冠心病患者血脂水平,抑制炎性反应,改善冠状动脉血循环,从而提高疗效,改善心功能。

Effects of Gualou Xiebai Guizhi Decoction on Elderly Patients with Coronary Heart Disease

To explore the effects of Gualou Xiebai Guizhi Decoction on blood lipid,NT-proBNP,hs-CRP and FiB levels in elderly patients with coronary heart disease.Methods:A total of 78 elderly patients with coronary heart disease were selected in Affiliated Hospital of Tibet University for Nationalities were randomly divided into a control group(39 cases)and a study group(39 cases).The control group was treated with Western medicine,and the study group was treated with Gualou Xiebai Guizhi Decoction on the basis of the control group for 4 weeks.The changes of blood lipid,NT Pro BNP,hs CRP,FiB,WBC,Hcy,hemorheology and cardiac function were observed and compared before treatment in the 2 groups.After the treatment was completed,the effect evaluation was performed.Results:After treatment,TC,TG,HDL-C,NT-proBNP,hs-CRP,FIB,WBC,HCY,whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,red blood cell aggregation index in the study group were lower than those in the control group,and LDL-C,EDD,NEDD,LVEF,lVPFR were higher than those in the control group(P<0.05).Conclusion:Gualou Xiebai Guizhi Decoction can reduce the level of blood lipid,inhibit the inflammatory reaction,improve the blood circulation of coronary artery,so as to improve the curative effects and heart function.