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| 胃癌相关基因及其在治疗中应用的研究进展 | |
| 引用本文： | 乔炜,琚坚,罗金波,段才华,乔璐.胃癌相关基因及其在治疗中应用的研究进展[J].胃肠病学,2012,17(1):53-55. |
| 作者姓名： | 乔炜 琚坚 罗金波 段才华 乔璐 |
| 作者单位： | 1. 昆明医学院 650031 2. 昆明医学院第二附属医院干疗消化科 3. 第四军医大学西京医院综合诊疗科 |
| 摘 要： | 胃癌是我国最常见的恶性肿瘤之一,发病率和死亡率均较高。胃癌的发生由遗传和环境等诸多因素相互作用所致,是一个多因素、多基因、多步骤参与的癌变过程,涉及大量相关基因的结构和表达异常,其中c-met、Bmi-1、HER-2/neu和基质金属蛋白酶（MMP）-9等的活化在胃癌的发生、发展中起重要作用。本文就近年胃癌相关基因及其在胃癌治疗中的研究进展作一综述,旨在帮助理解胃癌发生、发展的分子机制,并为其基因靶向治疗提供一定的理论依据。 |
| 关 键 词： | 癌基因 胃肿瘤 RNA 小分子干扰 信号传导 |
Advances in Study on Gastric Cancer Related Genes and their Application in Treatment of Gastric Cancer |
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| QIAO Wei , JU Jian , LUO Jinbo , DUAN Caihua , QIAO Lu.Advances in Study on Gastric Cancer Related Genes and their Application in Treatment of Gastric Cancer[J].Chinese Journal of Gastroenterology,2012,17(1):53-55. | |
| Authors: | QIAO Wei JU Jian LUO Jinbo DUAN Caihua QIAO Lu |
| Affiliation: | 1Graduate School of Kunming Medical University,Kunming(650031);2Department of Digestive Internal Medicine for Cadre,The Second Affiliated Hospital of Kunming Medical University,Kunming;3Department for Comprehensive Diagnosis and Treatment,Xijing Hospital,The Fourth Military Medical University,Xi’an |
| Abstract: | Gastric cancer is one of the most common malignant tumors with high prevalence and mortality.The genesis of gastric cancer is the result of the interaction between genetic and environmental factors,and is a multi-factor,multi-gene,and multi-step process involving structural and expression abnormalities of many related genes,of which the activation of gene c-met,Bmi-1,HER-2/neu and matrix metalloproteinase(MMP)-9 is of great importance.This article reviewed advances in study on gastric cancer related genes and their application in treatment of gastric cancer,for better understanding of molecular mechanisms of the occurrence and development of gastric cancer,so as to provide some theoretical basis for targeted gene therapy of gastric cancer. |
| Keywords: | Oncogenes Stomach Neoplasms RNA Small Interfering Signal Transduction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
