Bacteriophage-Derived Vectors for Targeted Cancer Gene Therapy |
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Authors: | Md Zahidul Islam Pranjol Amin Hajitou |
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Affiliation: | 1.Institute of Clinical and Biomedical Science, University of Exeter Medical School, Exeter, Devon EX1 2LU, UK; E-Mail: ;2.Phage Therapy Group, Department of Medicine, Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK |
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Abstract: | Cancer gene therapy expanded and reached its pinnacle in research in the last decade. Both viral and non-viral vectors have entered clinical trials, and significant successes have been achieved. However, a systemic administration of a vector, illustrating safe, efficient, and targeted gene delivery to solid tumors has proven to be a major challenge. In this review, we summarize the current progress and challenges in the targeted gene therapy of cancer. Moreover, we highlight the recent developments of bacteriophage-derived vectors and their contributions in targeting cancer with therapeutic genes following systemic administration. |
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Keywords: | bacteriophage CMV Grp78 AAVP HSVtk RGD4C-AAVP/CMV-HSVtk RGD4C-AAVP/Grp78-HSVtk glioblastoma |
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