胶质瘤组织中Per2和PCNA的表达及其相关性

目的观察胶质瘤组织中节律基因Per2和增殖细胞核抗原(PCNA)的表达变化,探讨其相关性及二者与胶质瘤临床病理特征的关系。方法采用免疫组化ABC法检测37例胶质瘤组织及瘤周组织中的Per2和PC-NA。结果胶质瘤组织中,Per2阳性表达率为29.7%(11/37),明显低于瘤周组织的62.2%(23/37);PCNA阳性表达率为100%,明显高于瘤周组织的0(P均<0.05)。高分化胶质瘤组织中Per2、PCNA强阳性表达率分别为16.7%8、8.9%,低分化者分别为42.1%、26.1%,二者Per2、PCNA的表达差异具有统计学意义(P均<0.05)。胶质瘤组织中Per2与PCNA的表达呈负相关(r=-0.492,P<0.05)。结论胶质瘤组织中Per2的表达下调、PCNA表达上调,Per2与PCNA的表达呈负相关关系;Per2、PCNA与胶质瘤分化程度有关。

Expression and correlation of Per2 and PCNA in glioma

Objective To investigate the expression and correlation of Per 2 and PCNA in glioma,and the relationship in Per 2 and PCNA with clinicopathologic features.Method The expression of Per 2 and PCNA in 37 cases of gliomas and nontumor tissues was detected by immunohistochemical ABC method.Results The positive rate of Per 2 was lower,and PCNA was higher in glioma tissue than that in nontumor one(all P<0.05).There was a negative correlation between the expression of Per 2 and PCNA in gliomas(r=-0.492,P<0.05).Conclusions The Per 2 is lowely and the PCNA is higherly expressed in glioma tissue,and there is a negative correlation.The expression of Per 2 and PCNA may be a mechanism in occurrence and progression of gliomas.