脑梗死患者血清MMP-9水平与动脉粥样硬化程度的相关性

目的探讨脑梗死（CI）患者血清基质金属蛋白酶9（MMP-9）水平与动脉粥样硬化（AS）程度的相关性。方法选择CI患者（观察组）及体检健康者（对照组）各30例，用ELISA法检测其血清MMP-9；彩色多普勒超声诊断仪检测其双侧颈总动脉、颈内动脉及颈动脉分又处的内中膜厚度（IMT）、粥样斑块及颈动脉管腔狭窄程度；分析观察组血清MMP-9与IMT的相关性。结果与对照组比较，观察组颈AS程度（IMT、不稳定斑块）、中度以上狭窄，以及血清MMP-9均明显高于对照组（P均〈0．01）；观察组不稳定性斑块患者的血清MMP-9明显升高（P〈0．01）。CI患者的血清MMP-9水平与IMT呈正相关（r=0．8961，P〈0．01）。结论血清MMP-9参与CI的病理生理过程，且与粥样斑块形成及其稳定性密切相关；CI患者血清MMP-9水平与IMT呈正相关，可反映AS程度。

Relationship between the level of serum Matrix Metalloproteinas-9 and the degree of atherosclerosis in cerebral infarction patients

Objective To investigate the correlation between the level of serum matrix metaUoproteinase-9 （MMP-9） and the degree of artherosclerosis in cerebral infarction （CI） patients. Methods A total of 60 people were enrolled into this study, 30 CI patients and 30 normal persons. The levels of serum MMP-9 were measured by ELISA. Four parametres, intimae-media thickness （IMT）, atheromatous plaque morphology and histology and stenosis of carotid of bilateral arteria carotis communis, arteria carotis interna and carotid bifurcation were studied by colour doppler flow imaging（CDFI）. Relation of MMP-9 and IMT in obser-ration group was analyzed. Results The degrees of carotid artery atherosclerosis in cerebral infarction patients were significantly severer than those in control group （ P 〈 0.01 ）. The levels of MMP-9 in serum were also significantly higher in cerebral infarction patients than those in control group. The levels of MMP-9 in serum significantly raise in the group of unstable plaque（ P 〈 0.01 ）. The serum MMP-9 content was positively correlated with IMT content（r = 0. 896 1, P 〈 0.01 ）. Conclusions Serum MMP-9 participates pathophysiology process of CI and is closely relative to the formation and stability of atherosclerosis. Serum MMP-9 could be a clinical mark relative to unstable plaque. Serum MMP-9 was closely relative to IMT in CI patients, and it can reflect the degree of atherosclerosis.