| 摘 要： | Gastric cancer is one of the most common tumorsworldwide.The therapeutic outcome of conventionaltherapies is inefficient.Thus,new therapeutic strategiesare urgently needed.Gene therapy is a promisingmolecular alternative in the treatment of gastric cancer,including the replacement of defective tumor suppressorgenes,the inactivation of oncogenes,the introduction ofsuicide genes,genetic immunotherapy,anti-angiogeneticgene therapy,and virotherapy.Improved molecularbiological techniques and a better understanding ofgastric carcinogenesis have allowed us to validate avariety of genes as molecular targets for gene therapy.This review provides an update of the new developmentsin cancer gene therapy,new principles,techniques,strategies and vector systems,and shows how they maybe applied in the treatment of gastric cancer.
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