Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats |
| |
Authors: | Akcan Alper Kucuk Can Sozuer Erdogan Esel Duygu Akyildiz Hizir Akgun Hulya Muhtaroglu Sabahattin Aritas Yucel |
| |
Affiliation: | 1. Department of Surgery,Erciyes University School of Medicine,Kaysed 38039,Turkey 2. Department of Microbiology,Erciyes University School of Medicine,Kayseri 38039,Turkey 3. Department of Pathology,Erciyes University School of Medicine,Kayseri 38039,Turkey 4. Department of Biochemistry,Erciyes University School of Medicine,Kayseri 38039,Turkey |
| |
Abstract: | AIM: To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerative colitis model. METHODS: Rats were randomly assigned to three groups: group I: control, group II: experimental colitis, group III: colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necrosis factor-alpha, portal blood endotoxin levels, colon tissue myeloperoxidase and caspase-3 activity were measured. Bacterial translocation was quantified by blood, lymph node, liver and spleen culture. RESULTS: We observed a significantly reduced incidence of bacterial translocation to the liver, spleen, mesenteric lymph nodes, portal and systemic blood in animals treated with melatonin. Treatment with melatonin significantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene sulphonic acid- treated rats (16.11 +/- 2.46 vs 32.97 +/- 3.91, P < 0.01). CONCLUSION: Melatonin has a protective effect on bacterial translocation and apoptosis. |
| |
Keywords: | Melatonin Colitis Bacterial translocation Apoptosis |
本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录! |
|