Molecular mechanisms implicated in SARS-CoV-2 liver tropism |
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Authors: | Jorge Quarleri M Victoria Delpino |
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Affiliation: | Jorge Quarleri, M. Victoria Delpino, Institute for Biomedical Research on Retroviruses and AIDS, Faculty of Medical Sciences, National Scientific and Technical Research Council-University of Buenos Aires, Buenos Aires 1121, Argentina |
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Abstract: | The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hepatic involvement is common in SARS-CoV-2-infected individuals. It is currently accepted that the direct and indirect hepatic effects of SARS-CoV-2 infection play a significant role in COVID-19. In individuals with pre-existing infectious and non-infectious liver disease, who are at a remarkably higher risk of developing severe COVID-19 and death, this pathology is most medically relevant. This review emphasizes the current pathways regarded as contributing to the gastrointestinal and hepatic ailments linked to COVID-19-infected patients due to an imbalanced interaction among the liver, systemic inflammation, disrupted coagulation, and the lung. |
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Keywords: | SARS-CoV-2 Viral hepatitis Non-infectious liver disease Hyperin-flammation Coronavirus disease 2019 |
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