冠心病危险因素与冠状动脉病变程度相关性的研究

目的探讨冠心病危险因素与冠状动脉病变程度之间的相关性。方法选择吉林大学第一医院2006年2月至2007年12月280例经冠状动脉造影确诊为冠心病的患者为研究对象。以Gensini积分、复杂病变(长病变、分叉病变、三支病变、左主干病变)发生率来评价冠状动脉病变严重程度。利用SAS 8.02软件分别进行单因素和多因素Logistic回归分析冠状动脉狭窄严重程度与相关危险因素的关系。结果年龄、体质量指数(BMI)增加、血脂异常与冠状动脉病变程度积分增加呈正相关,女性冠心病患者更容易发生长病变,BMI超标的冠心病患者更易发生三支病变。结论冠心病患者中高龄、体质量指数增加、血脂异常与冠状动脉病变程度呈正相关,而性别与长病变的发生率密切相关,体质量指数与三支病变密切相关。

The correlation between the severity of coronary artery stenosis and its risk factors

Objective To evaluate the relationship between the severity of coronary artery stenosis and its risk factors.Methods Two hundred eighty patients diagnosed with coronary heart disease(CHD) by coronary angiography in the first hospital of Jilin University between February 2006 and December 2007 were enrolled.By the Gensini score and the incidence of complicated coronary artery stenosis,the severity of CHD was determined.Single factor analysis and multivariate analysis between CHD severity and its risk factors were calculated by SAS 8.02 software.Results The single factor analysis showed only sex,body mass index(BMI) and blood cholesterol level were related to Gensini scores and high BMI was related to the incidence of three-vessel disease.Logistic multivariate analysis showed that advanced age,high BMI and abnormal blood cholesterol level were correlated positively with Gensini scores.Females were more likely to suffer from long lesions of coronary artery.Patients with high BMI were more likely to have three-vessel disease.Conclusions The advanced age,increased BMI and dyslipidemia are related to the severity of coronary artery stenosis.Long coronary lesions are more common in females and three-vessel disease is more common in the patients with high BMI respectively.