| 氢氯噻嗪联合盐酸贝那普利对非杓型高血压患者血压水平的影响 |
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| 引用本文： | 牟秀霞,胡元会,石洁.氢氯噻嗪联合盐酸贝那普利对非杓型高血压患者血压水平的影响[J].中西医结合心脑血管病杂志,2011,9(7):783-785. |
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| 作者姓名： | 牟秀霞 胡元会 石洁 |
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| 作者单位： | 中国中医科学院广安门医院,100053 |
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| 摘 要： | 目的按照时间治疗学原则,探讨不同时间服用氢氯噻嗪和盐酸贝那普利对新发1级、2级非杓型高血压患者血压水平的影响。方法对62例非杓型高血压患者随机分为早氢氯噻嗪+早盐酸贝那普利组(早早组)和早氢氯噻嗪+晚盐酸贝那普利组(早晚组),共治疗8周。服药前后进行诊室血压测量和动态血压监测,观察药物对血压水平及血压昼夜节律的影响。结果治疗后两组诊室收缩压(SBP)和舒张压(DBP)均较治疗前明显下降(P<0.05);两组间诊室SBP和DBP在治疗前后差异无统计学意义。动态血压结果显示,两组患者的24 hSBP和24 hDBP水平均较治疗前有明显下降(P<0.01)。早晚组患者的夜间SBP和DBP达标率明显高于早早组(P<0.01)。在血压昼夜节律纠正方面,早早组将非杓型纠正为杓型血压的比例为20%,早晚组将非杓型纠正为杓型的比例为40%(P<0.01)。结论对于新发1级和2级非杓型高血压患者,联合服用氢氯噻嗪和盐酸贝那普利可以有效控制血压。晚上服用盐酸贝那普利可以较好地纠正夜间的高负荷血压,维持正常的昼夜变化节律。
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| 关 键 词： | 氢氯噻嗪 盐酸贝那普利 非杓型高血压 时间治疗学 |
The Pharmacological Effects of Combination Therapy of Hydrochlorothiazide and Benazepril On Abnormal Blood Pressure Circadian Rhythm in Newly-onset Hypertension |
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| Mou Xiuxia,Hu Yuanhui,Shi Jie.The Pharmacological Effects of Combination Therapy of Hydrochlorothiazide and Benazepril On Abnormal Blood Pressure Circadian Rhythm in Newly-onset Hypertension[J].Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease,2011,9(7):783-785. |
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| Authors: | Mou Xiuxia Hu Yuanhui Shi Jie |
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| Affiliation: | Mou Xiuxia,Hu Yuanhui,Shi Jie Department of Cardiovascuology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences(Beijing 100053) |
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| Abstract: | Objective To investigate the pharmcochronological effect of combination therapy of hydrochlorothiazide and benazepril on blood pressure(BP)and circadian rhythm in patients with newly-onset,grade A and B hypertension.Methods Sixty two patients with non-dipper pattern of night BP were treated with combination of hydrochlorothiazide(morning dose) and benazepril(morning dose or evening dose)for 8 weeks.Results Both programs decreased office systolic blood pressure(SBP) and diastolic blood pressure(DBP) with no ... |
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| Keywords: | hydrochlorothiazide benazepril non-dipper hypertension chronotherapy |
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