| 环维黄杨星D对PC12谷氨酸损伤的保护作用的实验研究 |
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| 引用本文： | 袁冬平,龙军,方泰惠.环维黄杨星D对PC12谷氨酸损伤的保护作用的实验研究[J].中西医结合心脑血管病杂志,2004,2(1):37-38. |
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| 作者姓名： | 袁冬平 龙军 方泰惠 |
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| 作者单位： | 1. 南京中医药大学药理教研室
2. 中国药科大学生物制药学院 |
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| 摘 要： | 目的:探讨环维黄杨星D(CBV-D)对PC12细胞谷氨酸(Glu)损伤模型的影响.方法:用Glu复制PC12细胞兴奋性氨基酸损伤模型,通过MTT染色和乳酸脱氢酶(LDH)活性的测定来研究CBV-D对PC12细胞的保护作用.结果:CBV-D抑制Glu造成的损伤,降低LDH的漏出.结论:CBV-D对兴奋性氨基酸引起PC12细胞损伤具有保护作用.
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| 关 键 词： | 环维黄杨星D PC12细胞 兴奋性氨基酸 |
| 文章编号： | 1672-1349-(2004)01-0037-02 |
| 修稿时间： | 2003年12月10 |
Protective Effect of CBV-D on Glu-induced Injury in Cultured PC12 Cells |
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| Yuan Dongping,Long Jun,Fang Taihui.Protective Effect of CBV-D on Glu-induced Injury in Cultured PC12 Cells[J].Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease,2004,2(1):37-38. |
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| Authors: | Yuan Dongping Long Jun Fang Taihui |
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| Affiliation: | Jiangsu 210029 |
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| Abstract: | Objective:To investigate the effects of CBV-D on Glu-induced injury in cultured PC12 cells. Methods:Cultured PC12 cells were treated with Glu. The protective effect of CBV-D were evaluated by lactatedehydrogenate(LDH) efflux assay and colorimetric MTT assay. Results:CBV-D significantly antagonized LDH efflux and increased the optical density at 570 nm tested by colorimetric MTT assay. Conclusion:CBV-D can protect PC12 cells from Glu-induced injury. |
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| Keywords: | CBV-D PC12 cultured cell Glu-induced injury |
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