慢性丙型肝炎患者甲状腺功能异常情况观察

目的 了解慢性丙型肝炎患者甲状腺疾病发生情况及其与肝功能、病毒复制、肝硬化发生及合并症的关系.方法 检测133例未接受干扰素治疗的慢性丙型肝炎患者血清中总三碘甲状腺原氨酸、总甲状腺素、游离三碘甲状腺原氨酸、游离甲状腺素和促甲状腺激素(thyroid stimulating hormone,TSH),并收集患者临床资料,...

Observation of thyroid dysfunction in patients with chronic hepatitis C

Objective To investigate the occurrence of thyroid diseases and its relationship with liver function,viral replication,the development of liver cirrhosis and complications in patients of chronic hepatitis C(CHC).Methods Serum total triiodothyrone,total thyroixine,free triiodothyrone,free thyroixine and thyroid stimulating hormone(TSH) of 133 HCV patients were detected and clinical data were investigated to analyze the impact of the development of thyroid diseases on the disease state of CHC.Results Of 133 CHC patients,16 developed thyroid disorders,3 with hyperthyroidism,7 with hypothy-roidism and 6 with subclinical hypothy-roidism.Another 2 patients had been diagnosed with low T3 syndrome.The levels of ALT,AST,TP and HCV RNA,the occurrence of liver cirrhosis and complications were not significantly different between the normal thyroid function group and the thyroid dys-function group,and ALB level of the thyroid dysfunction group was significantly lower than that of the normal thyroid function group.Conclusions Of 133 CHC patients,12% have thyroid dysfunction,and the detection of serum TSH is more sensitive than that of other thyroid hormones.Thyroid dysfunction has no impact on liver function and HCV replication in the CHC patients.