| 调节性T细胞稳态与慢性HIV-1感染引起的异常免疫活化研究 |
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| 引用本文： | 邢少军,福军亮,周春保,金磊,王福生.调节性T细胞稳态与慢性HIV-1感染引起的异常免疫活化研究[J].传染病信息,2009,22(6):338-341. |
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| 作者姓名： | 邢少军 福军亮 周春保 金磊 王福生 |
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| 作者单位： | 1. 中国科学院生物物理研究所,北京,100101;解放军传染病研究所,北京,100039
2. 解放军传染病研究所,北京,100039 |
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| 基金项目： | 国家"十一五"传染病重大专项 |
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| 摘 要： | 目的本研究旨在探讨CD4＋Foxp3＋调节性T细胞（regulatory Tcells，Treg）稳态与慢性HIV-1感染者疾病进程及免疫活化的相关性。方法选择50例慢性HIV-1感染者，包括AIDS患者15例（AIDS组）、典型进展（typical progressor，TP）患者25例（TP组）、长期非进（long-term non-progressor，LTNP）患者10例（LTNP组），另选健康对照者（healthy control，HC）15例（HC组）。用流式细胞仪检测Treg的增殖标志Ki-67和凋亡标志半胱氨酰天冬氨酸蛋白酶-3，同时检测Treg的活化标志CD38和人白细胞抗原-DR。结果在HC组和慢性HIV-1感染者中，Treg的增殖和凋亡速率均显著高于CD4＋Foxp3非调节性T细胞，这种稳态的改变在TP组和AIDS组中更为明显。进一步研究发现Treg增殖和凋亡与其活化程度呈正相关。结论慢性HIV-1感染导致Treg的过度活化，进而导致Treg稳态的改变。Treg稳态可以作为预测HTV/AIDS患者疾病进展的一项指标。
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| 关 键 词： | Foxp3 调节性T细胞 免疫活化 HIV-1 稳态 |
Immune hyperactivation correlated with CD4~+ Foxp3~+ regulatory T cells homeostasis in chronic HIV-1 infection |
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| Xing Shaojun,Fu Junliang,Zhou Chunbao,et al..Immune hyperactivation correlated with CD4~+ Foxp3~+ regulatory T cells homeostasis in chronic HIV-1 infection[J].Infectious Disease Information,2009,22(6):338-341. |
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| Authors: | Xing Shaojun Fu Junliang Zhou Chunbao |
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| Affiliation: | Xing Shaojun,Fu Junliang,Zhou Chunbao,et al. Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China |
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| Abstract: | Objective To investigate the correlation of the homeostasis of CD4+Foxp3+ regulatory T cells (Treg) with the disease pro-gression and immune activation in patients with chronic HIV-1 infection. Methods Fifty HIV-1-infected subjects including 15 AIDS patients (AIDS group),25 typical progressors (TP group),10 long-term non-progressors (LTNP group),and 15 healthy controls (HC group) were enrolled in this study. Treg proliferation and apoptosis from peripheral blood were evaluated by detecting intracellular Ki-... |
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| Keywords: | Foxp3 HIV-1 |
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