| TRAIL及其受体促凋亡机制与消化道肿瘤治疗的前景 |
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| 引用本文： | 朱颖,YUAN Yao-zong.TRAIL及其受体促凋亡机制与消化道肿瘤治疗的前景[J].国际消化病杂志,2008,28(2):155-158. |
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| 作者姓名： | 朱颖 YUAN Yao-zong |
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| 作者单位： | 上海交通大学医学院附属瑞金医院消化科,200025 |
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| 摘 要： | 肿瘤坏死因子相关凋亡诱导配体(TRAIL)因其选择性诱导肿瘤细胞凋亡的特点而受到关注.TRAIL促肿瘤细胞凋亡的机制及其受体对它的调控机制尚在探索中.目前,TRAIL及其受体已被广泛运用于消化道肿瘤的治疗研究中,不同的消化道肿瘤细胞株对TRAIL诱导的凋亡敏感性不同,某些细胞株对TRAIL耐药.克服肿瘤细胞对TRAIL的耐药,同时保护正常细胞免受伤害,充分发挥TRAIL选择性杀伤肿瘤细胞的优点,将使TRAIL在抗癌方面发挥积极的作用.
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| 关 键 词： | 肿瘤坏死因子相关凋亡诱导配体 凋亡 胃肠道肿瘤治疗 |
Mechanism of TRAIL and TRAIL-R induced apoptosis and the prospect of its roles on gastrointestinal tumor therapy |
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| ZHU Ying,YUAN Yao-zong.Mechanism of TRAIL and TRAIL-R induced apoptosis and the prospect of its roles on gastrointestinal tumor therapy[J].International Journal of Digestive Disease,2008,28(2):155-158. |
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| Authors: | ZHU Ying YUAN Yao-zong |
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| Abstract: | Close attention is paid to selective killing of tumor cells induced by TNF related apoptosis induced ligand(TRAIL) without significant systemic cell toxicity.The mechanism of TRAIL induces apoptosis and it's receptor regulation is unknow.More and more studies of TRAIL and TRAIL-R focus on it's therapeutical effects of gastrointestinal tumor.Various gastrointestinal tumor cell lines show different sensibility to TRAIL induces apoptosis.Several cell lines show resistance to TRAIL.To solve the drug resistance of tumor cells and protect the normal cells will bring the virtue of TRAIL which can kill tumor cell without systemic cell toxicity into full play on tumor therapy. |
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| Keywords: | TRAIL Apoptosis Gastrointestinal tumor therapy |
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