| “失功能”HDL与动脉粥样硬化 |
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| 引用本文： | 赵小杰,喻红.“失功能”HDL与动脉粥样硬化[J].中国动脉硬化杂志,2022,30(3):185-191. |
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| 作者姓名： | 赵小杰 喻红 |
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| 作者单位： | 武汉大学基础医学院生物化学与分子生物学系湖北省发育源性疾病重点实验室 |
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| 基金项目： | 国家自然科学基金面上项目(82070471、81670423、81270364)。 |
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| 摘 要： | 高密度脂蛋白(HDL)具有介导胆固醇逆向转运、抗氧化、抗炎、保护内皮等功能而被公认为动脉粥样硬化的重要防御因素。但在炎症、代谢性疾病状态下,HDL发生组分改变、氧化或修饰,可转化为致动脉粥样硬化的"失功能"HDL,进而与心血管事件发生率的增加有关。本文概述"失功能"HDL的组成与功能特征,旨在为动脉粥样硬化性心血管疾病提供新的诊治手段。
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| 关 键 词： | 高密度脂蛋白 功能障碍 炎症 氧化 动脉粥样硬化 |
| 收稿时间： | 2021/8/21 0:00:00 |
| 修稿时间： | 2021/11/8 0:00:00 |
Dysfunctional high density lipoprotein and atherosclerosis |
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| ZHAO Xiaojie,YU Hong.Dysfunctional high density lipoprotein and atherosclerosis[J].Chinese Journal of Arteriosclerosis,2022,30(3):185-191. |
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| Authors: | ZHAO Xiaojie YU Hong |
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| Affiliation: | (Department of Biochemistry and Molecular Biology,Wuhan University School of Basic Medical Sciences&Hubei Provincial Key Laboratory of Developmentally Originated Disease,Wuhan,Hubei 430071,China) |
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| Abstract: | High density lipoprotein(HDL)is protective against atherosclerosis through multiple functions,including mediating reverse cholesterol transport,anti-oxidation,anti-inflammation,and endothelial protection.However,in the state of inflammation and metabolic diseases,due to alteration,oxidation or modification of HDL composition,HDL particles can be transformed into proatherosclerotic“dysfunctional”HDL,which is associated with an increased incidence of cardiovascular events.This paper reviews the composition and functional characteristics of dysfunctional HDL in order to provide new diagnostic and therapeutic approaches for atherosclerotic cardiovascular disease. |
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| Keywords: | high density lipoprotein(HDL) dysfunction inflammation oxidation atherosclerosis |
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