| 联合应用丹酚酸和氨氯地平对高血压合并高脂血症大鼠的治疗作用 |
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| 引用本文： | 陈安,;马全鑫,;王俊,;王东之,;徐更华,;陶晓剑,;潘永明,;寿旗扬.联合应用丹酚酸和氨氯地平对高血压合并高脂血症大鼠的治疗作用[J].心电学杂志,2014(6):483-486. |
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| 作者姓名： | 陈安 ;马全鑫 ;王俊 ;王东之 ;徐更华 ;陶晓剑 ;潘永明 ;寿旗扬 |
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| 作者单位： | [1]浙江省绍兴市上虞中医医院心血管科,312300; [2]浙江中医药大学动物实验研究中心/比较医学研究中心,312300; |
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| 基金项目： | 浙江省医学会临床科研基金项目（2011ZYC-B4） |
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| 摘 要： | 目的：观察丹酚酸联合氨氯地平对高血压合并高脂血症大鼠的治疗作用。方法24只自发性高血压大鼠，高脂饲喂2周后，随机分成氨氯地平组、多达一（苯磺酸氨氯地平阿托伐他汀钙片）组、联合用药组和对照组4组，每组6只。连续给药4周，并继续饲喂高脂，测定大鼠给药前后的血压、血脂，血浆、肝和心肌组织中超氧化物歧化酶（SOD）和丙二醛（MDA）含量。结果治疗4周后，对照组血压升高，HDL- C降低（P＜0.05和0.01）；联合用药组血压、血TG、LDL- C、LDL- C /HDL- C、肝组织TC和TG水平，血浆和心肌组织MDA降低，SOD活性和SOD /MDA比值升高，与对照组比较差异有统计学意义（P＜0.05或0.01）；氨氯地平组和多达一组血压、LDL- C、LDL- C /HDL- C、肝组织TC水平、心肌组织MDA含量降低，心肌组织SOD/MDA比值升高，与对照组比较差异有统计学意义（P＜0.05或0.01），多达一组肝组织TG低于对照组，差异有统计学意义（P＜0.05）。结论丹酚酸联合氨氯地平能协同增强高血压合并高脂血症大鼠的降压和降脂作用，其作用与抑制脂质过氧化、保护血管内皮功能有关。
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| 关 键 词： | 丹酚酸 氨氯地平 高血压 高脂血症 |
Therapy effect of salvianolic acid with amlodipine on rats with hypertension and hyperlipidemia |
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| Affiliation: | CHEN An, MA Q.anxin. WANG Jun, etal.( Department of Cardiovascular Shangyu ttospital of Traditional Chinese Medcine,Shaoxin 312300, China) |
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| Abstract: | Objective To observe therapy effect of Salvianolic acid （SA） combined with amlodipine on rats with hypertension and hyperlipidemia. Methods 24 spontaneously hypertensive rats （SHR） fed high- fat diet for 2 weeks and then randomly fed amlodipine （AMl group, n=6）, amlodipine plus atorvastatin （AMLAT group, n=6）, SA plus amlodipine （SAAML group, n=6） or water （control group, n=6）, respectively, as well as high- fat diet for 4 weeks. Blood pressure, serum lipids, superoxide dismutase （SOD） and malondialdehyde （MDA） of plasma, liver and myocardium were measured before and after treatment. Results After 4 weeks treatment, blood pressure increased and HDL- C decreased significantly in control group（P〈0.05or0.01）. Serum TG, LDL- C, LDL- C/HDL- C, hepatic TC and TG decreased, plasma and myocardial MDA decreased, SOD and ratio of SOD/MDA increased significantly in SAAML group compared to control group （ al P〈0.05 or 0.01）. Blood pressure, LDL- C, LDL- C /HDL- C, hepatic TC, myocardial MDA decreased, myocardial SOD/MDA increased significantly in AML and AMLAT groups compared to control group（P〈0.05 or 0.01）. Hepatic TG was significantly lower in AMLAT group than control group （P〈0.05）. Conclusion Salvianolic acid combined with amlodipine may have synergetic effects on blood pressure and lipid lowering in SHR with hyperlipidemia. The possible mechanisms are related to inhibition of lipid peroxidation and protection of endothelial function. |
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| Keywords: | Salvianolic acid Amlodipine Hypertension Hyperlipidemia |
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