第三代头孢菌素引发消化道出血的机制分析

目的:阐述第三代头孢菌素引发消化道出血的可能机制.方法:对国内近30 a的相关文献进行综合回顾性分析.结果:第三代头孢菌素可导致多器官黏膜上皮的严重损害,表现为消化道黏膜损害并出血、呼吸道黏膜损害并出血,或尿道黏膜损害并出血;其他器官损害有心、肺、神经等.73例不良反应患者,消化道黏膜损害并出血6例,尿道黏膜损害并出血2例,呼吸道黏膜损害并出血1例.本组病例出血死亡率50%.结论:第三代头孢菌素导致多器官功能损害,其中引起消化道大出血发生率较其他不良反应发生率低,但死亡率较高,后果严重.

Analysis on the mechanism of gastrointestinal hemorrhage caused by the third-generation cephalosporins

AIM:To probe into the possible mechanism of gastrointestinal hemorrhage induced by the third generation of cephalosporins. METHODS:The related literatures in the past 30 years were collected and retrospective analyzed. RESULTS:The third generation of cephalospo- rins caused mucosal injury of various organs, such as gastrointestinal tract,respiratory tract or urinary tract,complicated with hemorrhage. Besides,the injuries also occurred in heart,lung, and nerve.Adverse reactions were found in 73 cases,of which 6 were confirmed with gastroin- testinal mucosal injury,2 with urinary mucosal injury,and 1 with respiratory mucosal injury, and the 9 cases were all complicated with hem- orrhage.The mortality rate associated with hem- orrhage was 50%. CONCLUSION:Multi-organ dysfunction can be caused by the third-generation cephalosporins. Gastrointestinal hemorrhage occurs less fre- quently that other adverse reactions,but it can lead to a higher mortality rate.