Fas/FasL系统表达与结直肠癌的研究进展

细胞凋亡是指在一定生理和病理情况下,机体为维护内环境的稳定而发生的主动性细胞死亡过程,即程序性死亡.由死亡受体与其配体相互作用是引起细胞凋亡的主要途径之一,其中Fas/FasL系统是被认为最主要的介导细胞凋亡的信号转导途径.大肠癌是严重威胁人类健康的常见恶性肿瘤之一,大肠癌的发生、发展与细胞凋亡的调节失衡有关.本文就Fas/ FasL系统表达与结直肠癌发生发展的关系及相关方面研究作一综述.

Progress in studies on the Fas/FasL expression system and colon carcinoma

Cell apoptosis or programmed cell death is the term used to describe active cell death to maintain stability under physiological and pathological conditions.Interaction of the death receptor and death ligand is one of the main ways to induce apoptosis,of which,the Fas/FasL system is considered as the major signal transduction pathway to mediate apoptosis.Colon carcinoma is one of the common malignant tumors that are a threat to human health.The occurrence and development of colon carcinoma is related to the regulation imbalance of cell apoptosis.This article reviews the relationship between the Fas/ FasL expression system and the occurrence and development of colon carcinoma.