皮质下缺血性血管病患者同型半胱氨酸与认知功能障碍的关系

目的探讨皮质下缺血性血管病(SIVD)患者同型半胱氨酸(Hcy)与轻度血管性认知功能障碍(MVCI)的相关性。方法将120例SIVD患者按照蒙特利尔认知评估量表(MOCA)评定的认知功能程度的不同,分为MVCI组(56例)和非MVCI组(64例),检测Hcy、叶酸、VitB_(12)水平,MVCI组患者治疗3个月后,再进行MOCA评分及上述指标检测,并进行分析。结果 MVCI组血浆Hcy水平明显高于非MVCI组;血清叶酸、VitB_(12)水平显著低于非MVCI组(P0.01)。Hcy水平与年龄呈正相关,与MOCA评分呈负相关(P0.01)。结论 Hcy可能是SIVD患者发生MVCI的独立危险因素,叶酸、VitB_(12)缺乏,间接引起Hcy增高,是导致MVCI的重要影响因素。

The relationship between homocysteine and cognitive function in patients with subcortical ischemic vascular disease

Objective To investigate the relations between mild vascular cognitive impairment (MVCI) and homocysteine(Hcy) ,folacin,vitamin B_(12) in patients with subcortical ischemic vascular disease(SIVD).Methods A total of 120 patients with SIVD were divided into MVCI group (56 patients) and non-MVCI group(64 patients)according to MOCA scale.The levels of Hcy,folic acid and vitamin B_(12) were measured.After three months of treatment,MOCA assessment and measurement of the levels of Hcy,folic acid and vitamin B_(12) were carried out.Results Serum Hcy level in the MVCI group was significantly higher than that in non-MVCI group;Serum folacin and vitamin B_(12) levels in the MVCI group were significantly lower than those in non-MVCI group (P < 0.01).The level of Hcy had positive correlation with age and negative correlation with MOCA score (P < 0.01).Conclusion Hcy may be an independent risk factor for MVCI in SIVD patients.Folacin and vitamin B_(12) deficiency is an important factor that may indirectly cause increase in Hcy and result in MVCI.