60例晚发型多发性硬化患者的临床分析

目的探讨晚发型多发性硬化的临床特点。方法从临床资料、辅助检查方面对60例晚发型多发性硬化患者进行回顾性分析。结果本组病例首次发病年龄50~71岁,平均年龄56.64岁,男女之比为11.73,55.0%患者亚急性起病,单症状发病者占60.0%,临床表现以运动障碍突出,感觉异常和括约肌障碍多见,脊髓MRI异常率达88%,以颈髓病变多见。结论晚发型多发性硬化临床表现与经典多发性硬化相似,但运动障碍重,脊髓损害多见,辅助检查对早期诊断尤为重要。

Clinical features of late-onset multiple sclerosis: analysis of 60 cases

Objective To summarize the features of late-onset multiple sclerosis(LOMS)in China.Methods The clinical manifestations and inducements of 60 LOMS patients were comprehensively analyzed using clinical statistical method.Results The age of onset was from 50 to 71 years and the mean age was 56.64.Gender prevalence was male:female=11.73.Fifty-five percents of LOMS were found to be subacute at onset and sixty percents presented single symptom.The initial symptoms were commonly sensory abnormalities and limb weakness.Motor dysfunction was severe and predominant.Sensory disturbance and sphincter dysfunction were common.Eighty-eight percents of patients showed abnormal MRI of spinal cord,and cervical cord was mostly involved.Sensory evoked potential was sensitive for LOMS.Electromyography showed that peripheral nervous system damage might occur in LOMS.Conclusion LOMS is similar to classical MS.MRI and evoked potentials can help its diagnosis.