心脏肾上腺素受体及其自身抗体研究进展

作为交感神经递质的去甲肾上腺素(norepinephrine,NE)及内分泌激素的肾上腺素(adrenaline,Ad)参与体内多数器官功能的调节,而这种调节都要通过靶器官上的肾上腺素受体(adrenergic receptor,AR)来实现。此外,在所有G蛋白耦联的膜表面受体中,AR是目前相对了解最清楚的一种,因而AR又可作为研究整个G蛋白耦联受体家族的一个理想模型。自Friou(1957年)等首先在系统性红斑狼疮(systemic lupus erythematosus,SLE)病人血清中发现抗核抗体(anti-nuclear antibody,ANA)以来,人们在自身免疫性疾病,心脏病病人甚至健康人血清中检测出越来越多的抗不同抗原的自身抗体,并对其功能进行了一些研究。现综述近年来AR及其自身抗体的研究进展。

Cardiac Adrenergic Receptor and Its Autoantibody

Norepinephrine (as a sympathetic transmitter) and adrenaline (as an endocrine hormone) are involved in the regulation of the function of most organs. This regulation depends on the adrenergic receptors (AR) on the target organ. The adrenergic receptor has been investigated in detail in all kinds of guanine nucleotide regulatory proteins. Therefore, AR can be researched as an ideal model in all guanine nucleotide regulatory proteins. In 1957 Friou et al first discovered anti-nuclear antibodies. Since then, increasing numbers of anti-different antigens antibodies have been detected in the sera of autoimmune diseases, cardiac diseases and in healthy people. This article gives an overview of the progress in research into AR and AR antibody in recent years.