吡喹酮与槟榔-南瓜子治疗带绦虫病的疗效比较

目的 比较吡喹酮与槟榔-南瓜子治疗带绦虫病的疗效,总结治疗经验,提高治疗水平。方法 回顾性分析2014-2019年收治的250例患者资料,分吡喹酮治疗组142例,槟榔-南瓜子治疗组108例,进行疗效比较。结果 吡喹酮组治愈率为93.66%,槟榔-南瓜子组为91.67%,差异无统计学意义(P >0.05)。治疗后24 h粪便检查,吡喹酮组总获虫率为84.51%,槟榔-南瓜子组为81.48%,差异无统计学意义(P >0.05);但槟榔-南瓜子组获全虫率高于吡喹酮组,差异有统计学意义(P <0.05)。槟榔-南瓜子组平均获虫时间为(236.20±173.49)min,长于吡喹酮 组的(82.41±51.36)min。槟榔-南瓜子组出现消化道不良反应例数较吡喹酮组多,但吡喹酮组不良反应较严重,少数病例出现神经系统不良反应。结论 吡喹酮、槟榔-南瓜子治疗带绦虫病疗效肯定。吡喹酮治疗方便快捷,宜在医院进行治疗;槟榔-南瓜子治疗可作为带绦虫病普查治疗首选。

Comparison on the curative effect of praziquantel and arecanuts and pumpkin seeds in the treatment of taeniasis

Objective To compare the curative effect of oral praziquantel and areca nut decoction plus use of raw pumpkin seeds in the treatment of taeniasis for improving the level of treatment via summarizing the therapy experience in this infection.Methods The clinical data were retrospectively analyzed in 250 cases of taeniasis from 2014 to 2019.The patients were divided into praziquantel group(n=142)and areca nut decoction plus pumpkin seeds group(n=108).Then the therapeutic efficacies were compared between group.Results The cure rate was 93.66%and 91.67%,respectively for praziquantel group and areca nut decoction plus pumpkin seeds group.The difference was insignificant(P>0.05).Examination of the feces within 24 hours after the treatment showed that the total rate of worms retrieved was 84.51%by praziquantel treatment and 81.48%by areca nut decoction plus pumpkin seeds therapy.The difference was not significantly different between the two groups(P>0.05),yet the rate of full worms retrieved was higher in patients treated with areca nut decoction plus pumpkin seeds than in those by praziquantel(P<0.05).The average time of deworming with praziquantel was(82.41±51.36)min,which was longer than that of areca nut decoction plus pumpkin seeds(236.20±173.49)min.More patients had adverse reactions of digestive tract treated by areca nut decoction plus pumpkin seeds,yet the symptoms were less serious than praziquantel,and the adverse reactions in nervous system were observed in several cases in praziquantel group.Conclusion Although praziquantel and areca nut decoction plus pumpkin seeds can have definite therapeutic effect in the treatment of taeniasis,yet praziquantel is appropriate for use on hospital basis because of its convenience and quickness.Treatment regimen by areca nut decoction plus pumpkin seeds may be the first choice for general survey of taeniasis.