| 妥泰加用治疗难治性癫痫的临床研究 |
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| 引用本文： | 朱遂强,罗利俊,王宏毅,阮旭中.妥泰加用治疗难治性癫痫的临床研究[J].临床内科杂志,2004,21(2):112-114. |
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| 作者姓名： | 朱遂强 罗利俊 王宏毅 阮旭中 |
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| 作者单位： | 1. 430020,武汉,华中科技大学同济医学院附属同济医院
2. 武汉市第一医院 |
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| 摘 要： | 目的 观察妥泰对难治性癫痫的疗效和不良反应。方法 对56例难治性癫痫患者，采用加用妥泰治疗，控制其发作。结果 妥泰加用治疗总有效率达83．7％，儿童组有效率达80．8％，成人组为86．9％，对各型难治性癫痫均有效。妥泰起效时间在4～8周达高峰(有效率达59.2％)。副作用发生率为35．7％，且均较轻。结论 妥泰加用治疗难治性癫痫疗效较好，是一种广谱、安全、耐受性好的新型抗癫痫药。
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| 关 键 词： | 癫痫／治疗 妥泰 |
| 文章编号： | 1001-9057(2004)02-0112-03 |
| 修稿时间： | 2003年8月29日 |
Clinical Investigation of the Treatment of Topiramate in Patients with Epilepsy |
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| ZHU Suiqiang,LUO Lijun,WANG Hongyi,et al..Clinical Investigation of the Treatment of Topiramate in Patients with Epilepsy[J].Journal of Clinical Internal Medicine,2004,21(2):112-114. |
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| Authors: | ZHU Suiqiang LUO Lijun WANG Hongyi |
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| Affiliation: | ZHU Suiqiang,LUO Lijun,WANG Hongyi,et al.Department of Neurology,Tonji Hospital,Tongji Medical College,Huazhong university of Science and Technology,Wuhan 430030,China |
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| Abstract: | Objective To observe and evaluate the therapeutical effect and the side effect of topiramate (TPM) in patients with intractable epilepsy( IE ) in an add-on therapy.Methods 56 patients with IE were observed, and they were given TPM by add-on therapy.Results In add-on therapy group, the effective rate of TMP achieved 83.7%.In the children group,the effective rate was 80.8% and in the adult group was 86.9%.It showed that the add-on therapy of TPM was effective to all of the seizure types of IE.The efficacy of TMP reached its peak after 4-8 weeks of treatment,side effects of this drug was minor and the incidence of it was 35.7%.Conclusion TPM had sound therapeutic effect in add-on therapy to the patients with IE.It is a new broad-spectrum,safe and well-tolerated antiepileptic drug. |
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| Keywords: | Epilepsy/ therapy Topiramate |
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