贝尼地平对冠心病患者一氧化氮和内皮素的影响

目的探讨钙离子拮抗剂贝尼地平对冠心病患者一氧化氮(NO)和内皮素(ET-1)的影响。方法将2006年1～7月对哈尔滨医科大学第四医院心内科36例冠心病患者给予贝尼地平2～4mg/d,治疗8周,测定用药前及服药后第4、8周NO和ET-1水平。以40名相匹配健康体检者为对照组给予安慰剂口服。结果冠心病患者的NO较对照组明显降低(7.46±3.36)μmol/L对(33.49±12.45)μmol/L,P<0.05],ET-1升高(79.60±10.04)ng/L对(59.50±6.28)ng/L,P<0.05]。贝尼地平治疗前后比较NO升高(28.24±14.92)μmol/L对(7.46±3.36)μmol/L,P<0.01],ET-1降低(60.01±13.84)ng/L对(79.60±10.04)ng/L,P<0.01]。结论贝尼地平能升高冠心病患者的NO水平,降低ET-1水平,从而证明贝尼地平具有内皮保护作用。

Effect of benidipine on NO and ET-1 of patients with coronary heart diease

Objective To search for the effect of benidipine,a kind of Ca2 blocker,on NO and ET-1 of patients with coronary heart disease.Methods Benidipine(2~4 mg/d)were given to the patients with coronary heart disease diagnosed definitely for 8 weeks.Forty healthy candidates were enrolled in the control group,and their morning fasting blood were tested for NO and ET-1 levels at the 4th,8th week in order to compare with the control group.Results Blood NO level of CHD patients was lower and blood ET-1 level was higher than the control group remarkably.After treatment NO level was increased and ET-1 level was decreased separately.Conclusion Benidipine can increase NO level and decrease ET-1 level,which demonstrated the protective effect of benidipine for endothelia.