| 核苷类似物联合人工肝治疗慢性重型肝炎疗效观察 |
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| 引用本文： | 李谦,唐克诚,袁桂玉,杨积明,李海,韩贵兰,刘国旺.核苷类似物联合人工肝治疗慢性重型肝炎疗效观察[J].临床肝胆病杂志,2007,23(4):255-257. |
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| 作者姓名： | 李谦 唐克诚 袁桂玉 杨积明 李海 韩贵兰 刘国旺 |
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| 作者单位： | 天津市传染病医院,天津,300192 |
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| 摘 要： | 研究核苷类似物联合人工肝治疗慢性乙型重型肝炎疗效。将58例慢性乙型重型肝炎患者分为三组,核苷类似物联合人工肝治疗组、单用人工肝治疗组、单用核苷类似物治疗组,观察治疗效果。联合治疗组病死率22.22%,胆红素下降明显,白蛋白回升,凝血酶原活动度好转,HBV DNA转阴或载量下降。血浆置换治疗可降低血清HBV DNA水平。核苷类似物联合人工肝治疗可加快肝功能好转,缩短病程,降低病死率,降低血清HBV DNA水平。
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| 关 键 词： | 人工肝 核苷类似物 HBVDNA 治疗 |
| 文章编号： | 1001-5256（2007）04-0255-03 |
| 修稿时间： | 2006-08-22 |
The efficacy of nucleosides plus artificial liver support system on treating chronic severe hepatitis |
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| LI Qian, TANG Ke -cheng, YUAN Gui -yu,et al..The efficacy of nucleosides plus artificial liver support system on treating chronic severe hepatitis[J].Chinese Journal of Clinical Hepatology,2007,23(4):255-257. |
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| Authors: | LI Qian TANG Ke -cheng YUAN Gui -yu |
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| Affiliation: | Tianjin Infectious Diseases Hospital, Tianfin 300192, China |
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| Abstract: | To study the efficacy of nucleosides plus artificial liver support system(ALSS) on treating chronic severe hepatitis.58 patients with chronic severe hepatitis B were divided into three groups: combined treating group with nucleosides plus ALSS,ALSS treating group and nucleosides treating group.The therapeutic efficacy was observed.In combined treating group,mortality was 25%,and liver function indexes,such as bilirubin,albumin,prothrombin time activity(PTA),and HBV DNA level,improved.Treating with nucleosides plus ALSS could accelerate the amelioration of liver function,shorten course of disease,decrease mortality and HBV DNA level. |
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| Keywords: | artificial liver support system(ALSS) nucleosides HBV DNA therapy |
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