| 环孢菌素A和吡喹酮合用治疗小鼠日本血吸虫病的研究 |
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| 引用本文： | 黄安生,盛琴华,曹岩,陈静卿,赵雪云,倪永晖.环孢菌素A和吡喹酮合用治疗小鼠日本血吸虫病的研究[J].中国病原生物学杂志,1996(3). |
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| 作者姓名： | 黄安生 盛琴华 曹岩 陈静卿 赵雪云 倪永晖 |
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| 作者单位： | 长江水利委员会血防办公室，湖北医科大学血吸虫病研究室 |
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| 摘 要： | 环孢菌素Ａ（ＣｓＡ）和吡喹酮（ＰＱＴ）联合应用对小鼠日本血吸虫感染后肉芽肿形成阶段的保护作用进行了观察。结果显示，在用药后的早期阶段，联合用药组的肝脏虫卵肉芽肿（ＨＥＧ）面积和血清过氧化脂质（ＬＰＯ）水平显著小／低于单独应用ＰＱＴ组；两组红细胞超氧化物歧化酶（ＳＯＤ）活性无显著性差异。表明ＣｓＡ和ＰＱＴ联合应用对日本血吸虫病的治疗作用优于ＰＱＴ单独使用。
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| 关 键 词： | 日本血吸虫病 环孢菌素A 吡喹酮 |
STUDIES OF THE COMBINED USE OF CYCLOSPORIN A AND PRAZIQUANTEL IN THE TREATMENT OF SCHISTOSOMIASIS IN MICE |
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| Huang An-Sheng, Sheng Qin-Hua, Cao Yan.STUDIES OF THE COMBINED USE OF CYCLOSPORIN A AND PRAZIQUANTEL IN THE TREATMENT OF SCHISTOSOMIASIS IN MICE[J].Journal of Pathogen Biology,1996(3). |
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| Authors: | Huang An-Sheng Sheng Qin-Hua Cao Yan |
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| Affiliation: | Huang An-Sheng; Sheng Qin-Hua; Cao Yan (Schistosomiasis Control Office of Changjiang Water-Conservancy Committee Wuhan 430010) Chen Jing-Qing; Zhao Xue-Yun; Ni Yong-Hui (Schistosomiasis Laboratory of Hubei Medical University) |
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| Abstract: | We reported here the protective effects of the combined use of cyclosporin A and praziquantel on Schistosoma japonicum-infected mice at granuloma-forming stage. Our research showed that shortly after drug administration, the sizes of hepatic egg granulomas and the levels of serum lipid peroxide in the combined drug group were less than that in the group where cyclosporin A or praziquantel was used alone. These results suggested that the combined use of cyclosporin A and praziquantel was better than when either of the two was used alone in the treatment of Schistosomiasis japonicum. |
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| Keywords: | Cyclosporin A Praziquantel Schistosomiasis japonicum |
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