不同剂量阿苯达唑和甲苯咪唑对土源性线虫感染疗效的随机对照试验

目的观察单倍、三倍剂量阿苯达唑和甲苯咪唑治疗土源性线虫感染的效果。方法采用随机对照试验,对314位调查对象随机分为阿苯达唑(400mg)、甲苯咪唑(500mg)、三倍阿苯达唑(400mg,3d)、三倍甲苯咪唑(500mg,3d)等4组,对各药物组治疗蛔虫、钩虫、鞭虫和绦虫感染的疗效进行观察,计算治愈率和粪样虫卵下降率。结果阿苯达唑治疗钩虫的疗效优于甲苯咪唑,两药单倍剂量对钩虫的治愈率分别为69.1%和31.0%,三倍剂量组治愈率分别为92.0%和54。0%,虫卵下降率单倍剂量组为97.3%和83.6%,三倍剂量组为99.7%和96.4%。控制鞭虫感染,三倍剂量疗效优于单倍剂量。两驱虫药物单倍或三倍剂量对蛔虫感染疗效显著(治愈率在93.0%～96.8%之间,虫卵下降率均大于99.9%)。三倍剂量对绦虫感染的治愈率为100%,而单倍剂量仅为50%。结论治疗钩虫和鞭虫感染,三倍剂量方案可获得较高的治愈率。

Efficacy of different doses of albendazole and mebendazole against common soil-transmitted Helminths and Taenia spp.:A randomized controlled trial

Objective To survey the efficacy of albendazole and mebendazole against soil-transmitted helminths(STH) in oral single doses and triple doses of albendazole or mebendazole.Methods A randomized controlled trial was conducted with 314 individuals divided into a group given i) albendazole(400 mg);ii) mebendazole(500 mg);iii) a triple dose of albendazole(400 mg×3 d),or iv) mebendazole(500 mg×3 d).Efficacy against Ascaris lumbricoides,Trichuris trichiura,and Taenia spp.was observed by calculating the cure rate(CR) and fecal egg reduction rate(ERR).Results Albendazole cured significantly more hookworm infections than mebendazole,with a CR of 69.1% versus one of 31.0% in a single dose and a CR of 92.0% versus one of 54.0% for a triple dose.Albendazole resulted in an ERR of 97.3% versus one of 83.6% in a single dose and 99.7% versus one of 96.4% in a triple dose.A triple dose was more efficacious at controlling T.trichiura infection than was a single dose.Both drugs had significant efficacy against A.lumbricoides(CR: 93.0%-96.8%;ERR:>99.9%).The CR in response to Taenia spp.was 100% for a triple dose but only 50% for a single dose.Conclusion A triple-dose regimen is warranted to cure hookworm and T.trichiura.