| MBD2调控Th17优势分化与非Th2优势型哮喘 |
| |
| 引用本文： | 陈志锋,向旭东.MBD2调控Th17优势分化与非Th2优势型哮喘[J].国际呼吸杂志,2021,41(4). |
| |
| 作者姓名： | 陈志锋 向旭东 |
| |
| 作者单位： | 中南大学湘雅二医院呼吸内科，长沙 410011;中南大学湘雅二医院急诊医学科，长沙 410011 |
| |
| 摘 要： | 辅助性T细胞17(Th17)是近年发现的新CD4+T细胞亚群,主要通过分泌细胞因子白细胞介素17趋化中性粒细胞在气道募集而促进非Th2优势型哮喘的发生。甲基化-CpG结合域蛋白在DNA甲基化中具有调控作用,且能通过调控Th17分化而影响哮喘的进展。文中主要综述了近年甲基化-CpG结合域蛋白2调控Th17优势分化进而介导非Th2优势型哮喘的研究进展。
|
| 关 键 词： | 白细胞介素17 甲基化-CpG结合域蛋白2 辅助性T细胞17 非Th2优势型哮喘 |
MBD2 regulates the dominant differentiation of Th17 cells and non-Th2 dominant asthma |
| |
| Chen Zhifeng,Xiang Xudong.MBD2 regulates the dominant differentiation of Th17 cells and non-Th2 dominant asthma[J].International Journal of Respiration,2021,41(4). |
| |
| Authors: | Chen Zhifeng Xiang Xudong |
| |
| Affiliation: | (Department of Respiratory Medicine,the Second Xiangya Hospital,Central South University,Changsha 410011,China;Department of Emergency,the Second Xiangya Hospital,Central South University,Changsha 410011,China) |
| |
| Abstract: | T helper type 17(Th17)cells is a new subgroup of CD4+T cells discovered in recent years,which mainly promotes the occurrence of non-Th2 dominant asthma by secreting the cytokine interleukin-17 to chemoattract neutrophils to recruit in the airway.Methtyl-CpG binding domain protein plays a regulatory role in DNA methylation and can affect the progress of asthma by regulating Th17 differentiation.This article mainly reviews the recent research progress of methtyl-CpG binding domain protein 2 regulating the dominant differentiation of Th17 and then mediating non-Th2 dominant asthma. |
| |
| Keywords: | Interleukin-17 Methtyl-CpG binding domain protein 2 T helper type 17 Non-Th2 dominant asthma |
| 本文献已被 维普 万方数据 等数据库收录！ |
