电针治疗老年非痴呆血管性认知损害的随机对照试验

目的探究电针治疗老年非痴呆血管性认知损害(VCI-ND)的有效性和安全性。方法 2018年1月-2019年6月,收集上海中医药大学附属市中医医院门诊就诊的老年VCI-ND患者70例,随机分为观察组和对照组。观察组取百会、印堂、四神聪、神庭、脑户、人中、风池(双侧)、神门(双侧)、内关(双侧)及三阴交(双侧),电针治疗,留针30min,3次/周,共治疗8周。对照组取相同腧穴,予假电针治疗。治疗前后应用蒙特利尔认知评估量表(MoCA)、简易精神状态检查(MMSE)和改良Bathel指数量表(MBI)对疗效进行评价。结果治疗8周后,2组MoCA均升高,且观察组MoCA评分高于对照组(23.44±3.42)分vs (20.77±4.20)分](P=0.008);2组MMSE均升高,观察组MMSE评分高于对照组(24.78±2.24)分vs (22.23±3.24)分](P=0.001)。2组治疗前后MBI评分及差值比较,差异均无统计学意义。2组不良事件发生率比较差异无统计学意义(9.38% vs 3.33%,χ2=0.203,P=0.652)。结论电针可以一定程度上改善老年VCI-ND患者的认知损害程度,且安全性好,可能是防治老年VCI-ND患者的一种有效方法 。

Efficacy and safety of electro-acupuncture on vascular cognitive impairment without dementia in elderly patients:a randomized controlled trial

Objective To investigate the efficacy and safety of electro-acupuncture(EA) on vascular cognitive impairment without dementia in elderly patients.Methods A total of 70 elderly patients with vascular cognitive impairment without dementia were enrolled in Traditional Chinese Medicine Hospital of Shanghai City from January 2018 to June 2019 and randomly divided into the observation group and control group.The observation group was treated with EA at Baihui,Yintang,Sishencong,Shenting,Naohu,Renzhong,Fengchi(bilateral),Shenmen(bilateral),Neiguan(bilateral) and S any injiao(bilateral)acupoints.The needle was retained for 30 minutes,three times a week,for a total of 8 weeks.The control group took the same acupoints and treated with sham EA.The Montreal Cognitive Assessment(MoCA),Mini-Mental State Examination(MMSE)and Modified Barthel Index(MBI) were used to evaluate the curative effect before and after treatment.Results After 8 weeks of treatment,MoCA score of both groups increased,and MoCA score of observation group was higher than that of control group(23.44±3.42) points vs(20.77±4.20) points](P=0.008);MMSE score of both groups increased,and MMSE score of observation group was higher than that of control group (24.78±2.24) points vs(22.23±3.24) points](P=0.001).There was no significant difference in MBI score between the two groups before and after treatment.There was no significant difference in the incidence of adverse events between the two groups(9.38% vs 3.33%,χ2=0.203,P=0.652).Conclusion EA can relieve the cognitive impairment of elderly patients with vascular cognitive impairment without dementia to a certain extent,and has good safety.It may be an effective method to prevent and treat elderly patients with this disease.