电针与氢化麦角碱对血管性痴呆大鼠脑乙酰胆碱酯酶的作用

目的　探讨电针对血管性痴呆(VD)大鼠的学习记忆行为及乙酰胆碱酯酶(AChE)的影响。方法　将制成肾性高血压(RHR)后再造脑反复缺血拟VD的大鼠30只，随机分为模型组、电针组和药物组(用氢化麦角碱，DHET)各10只，共治疗28d。治疗后均以水迷宫检测学习记忆行为情况，并检测脑AchE含量。结果　电针组、药物组水迷宫潜伏期明显短于模型组(P＜0.05～P＜0.005)，电针组短于药物组(P＜0.05～P＜0.005)。在海马、纹状体，电针组和药物组的AchE含量显著高于模型组，而电针组又高于药物组(P＜0.05)。结论　电针能改善VD大鼠学习记忆能力，提高脑AchE含量并使之重新分布，其作用优于DHET。

Effect of electroacupuncture and hydergine on acetylcholinesterase in encephalon of experimental vascular dementia in rats

Objective To probe the effect of electr oacpuncture on vasculardementia and content of acetylcholin esterase(AchE ) in brain of rat.Methods 30 SD rats were made renal hypertension(RHR) by t he kidney arteries pinched with silver clip.After 42 days,their bilateral common carotid artery were blocked repeatedly to cause cerebral ischemia.The Hypertensi on-Vascular Dementia model was made.Then they were divided into model group,ele ct roacupuncture group and medicine group(Dihydroergotoxine,DHET) with 10 in each g roup.The course was 28 days.The ability of learning and memorizing was observed by water maze，and the content of AchE in brain was detected after treatment.Results The latent period of the electroacpuncture group and medicine group was shorter than that of the model group(P＜0.05～P ＜0.0 05)，and that of the electroacupuncture group was shorter than that of the medic ine group(P＜0.05～P＜0.005).At hippocampus and striatum the contents of Ac hE in the electroacupuncture and medicine group were higher than that of the mod el group.The electroacupuncture group was higher than the medicine group(P＜ 0.05).Conclusions It indicates that electroacupuncture therapy c an promote the ability of learning and memorizing and enhance the content of Ach E in the brain of VD.Its therapeutic effect is better than DHET.