| 血小板膜及血清P选择素在急性冠脉综合征中的临床意义 |
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| 引用本文： | 魏文斌,刘伟,张新霞,胡雪松,许香广.血小板膜及血清P选择素在急性冠脉综合征中的临床意义[J].岭南心血管病杂志,2009,15(5):363-365,375. |
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| 作者姓名： | 魏文斌 刘伟 张新霞 胡雪松 许香广 |
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| 作者单位： | 深圳市第四人民医院; |
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| 摘 要： | 目的 探讨血小板膜P选择素的表达率及血清P选择素的浓度在急性冠脉综合征(acute coronarysyndrome,ACS)中的临床意义.方法 采用间接免疫荧光流式细胞术和双抗夹心酶联免疫测定法分别检测30例ACS患者、20例稳定型心绞痛(stable angina,SA)患者和25例正常对照者(经冠状动脉造影检查提示冠状动脉正常)血小板膜P选择素表达率和血清P选择素浓度,并进行统计分析.结果 ACS组血小板膜P选择素表达率显著高于SA组(17.19±8.05)%vs.(13.09±6.25)%,P<0.05],并显著高于对照组(17.19±8.05)%vs.(10.83±5.76)%,P<0.05],SA组和对照组之间比较,差异无统计学意义(P>0.05).ACS组血清P-选择素的浓度显著高于SA组(43.98±14.71)ng/ml vs.(36.14±13.42)ng/ml,P<0.05],并显著高于对照组(43.98±14.71)ng/ml vs.(33.34±11.05)ng/ml,P<0.05],SA组和对照组比较,差异无统计学意义(P>0.05).冠状动脉性心脏病(冠心病)患者血小板膜P选择素表达率与血清P-选择素浓度呈正相关(r=0.295,P=0.017).结论 检测血清P选择素浓度对预测ACS发生、发展有重要的参考价值.
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| 关 键 词： | 冠状动脉疾病 P选择素 动脉粥样硬化 |
Value of platelet membrane P-selectin and serum P-selectin in patients with acute coronary syndrome |
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| WEI Wen-bin,LIU Wei,ZHANG Xin-xia,HU Xue-song,XU Xiang-guang.Value of platelet membrane P-selectin and serum P-selectin in patients with acute coronary syndrome[J].South China Journal of Cardiovascular Diseases,2009,15(5):363-365,375. |
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| Authors: | WEI Wen-bin LIU Wei ZHANG Xin-xia HU Xue-song XU Xiang-guang |
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| Affiliation: | Department of Cardiology;The Fourth People's Hospital of Shenzhen;Shenzhen Guangdong 518033;China |
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| Abstract: | Objectives To investigate the clinical value of the expression rate of P-selectin on the platelet membrance and the concentration of serum P-selectin in patients with acute coronary syndrome (ACS). Methods The expression rate of P-selectin on the platelet membrane and the concentration of serum P-selectin in 30 ACS patients, 20 stable angina ( SA) patients and 25 healthy subjects were measured by flow cytometry ( FCM) and enzyme linked immunosorbent assay (ELISA). Results The expression rate of P-selectin o... |
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| Keywords: | coronary heart disease P-Selectin atherosclerosis |
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