左氧氟沙星治疗耐多药肺结核近期疗效观察

目的　观察左氧氟沙星对耐多药肺结核的近期疗效。方法 92例耐多药肺结核患者随机分为治疗组 50例和对照组 42例，化疗方案分别是 3HKZThV/18HZTh，3HKZTh/18HZTh，观察两组痰菌阴转、病变吸收和症状改善情况。结果 治疗组 3月和 6月的痰菌阴转率、病变吸收率、症状改善率分别是 40.0%，58.0%；54.0%，72.0%；66.0%，76.0%，对照组分别是 19.0%，35.7%；33.3%，42.9%；38.1%，45.2%，两组之间有显著性差异 (P＜0.05)。结论 左氧氟沙星联合其他化疗药物 3月强化治疗耐多药肺结核效果明显。

The effect of Levofloxacin on treating MDR-TB

Objective To observe the effect of Levofloxacin on treating MDR-TB. Methods Divide 92 cases into two groups in a randomized way , 50 of them was study group , the rest was control group. Therapy for 2 groups were 3HKZThV/18HZTh and 3HKZTh/18HZTh respectively, then observe the changes in sputum bacteria , focus and symptoms of two groups.Results The rate of sputum bacteria negtive , focus shrinking and symptoms improving of study group were 40.0%,58.0%; 54.0% ,72.0%; 66.0%, 76.0% respectively after three months and six months. That of control group were 19.0%,35.7%;33.3%,42.9%;38.1%,45.2% respectively .There is significant difference between two groups(P<0.05).Conclusion Significant results were achieved when choosing Levofloxacin combined with other medicine for treating MDR-TB enforcedly.