肝细胞癌癌前病变的诊断和治疗多学科专家共识(2020版)

肝癌目前占我国癌症死因的第二位。我国肝癌的发病特点大多遵循乙型肝炎-肝硬化-肝癌的"三步曲"模式。癌前病变的筛查在胃癌、大肠癌和宫颈癌等恶性肿瘤的诊治中已取得了显著的成果。肝硬化状态下的不典型增生结节具有较强的恶变潜能,尤其是高级别不典型增生结节癌变率极高。基于国内外在这一领域的研究成果和专家临床经验,《肝细胞癌癌前病变的诊断和治疗多学科专家共识(2020版草案)》经多学科协作对肝脏高级别不典型增生结节作为肝癌的癌前病变,从概念、筛查、诊断、治疗和随访等各方面进行了归纳和界定,旨在提出和建立肝癌癌前病变的概念和诊疗原则,为降低我国肝癌的发病率和提高肝癌的总体治疗效果作出贡献。

Expert consensus on multidisciplinary diagnosis and treatment of precancerous lesions of hepatocellular carcinoma(2020 edition)

Hepatocellular carcinoma(HCC)currently holds the second position for cause of cancer-related deaths in China.Most of the pathogenic characteristics of HCC in China follow the tri-step model of hepatitis B-cirrhosis-liver cancer.The screening of precancerous lesions of stomach cancer,colorectal cancer and cervical cancer has achieved remarkable results for the diagnosis and treatment of malignant tumors.Dysplastic nodules in the state of cirrhosis have strong potential for malignant changes,especially high-grade dysplastic nodules,have extremely high canceration rate.This expert consensus is based on the research results and clinical experience of foreign and native experts of this field.Furthermore,this consensus summarizes and defines high-grade dysplastic nodules of the liver as precancerous lesions of HCC through multidisciplinary collaboration in terms of conception,screening,diagnosis,treatment and follow-up,with the aim to reduce the HCC incidence and improve the overall therapeutic effect of HCC in China.