冠心病患者体内脂质过氧化损伤及其红细胞膜流动性变化的临床观察

目的 :观察冠心病 ( CHD)患者体内脂质过氧化损伤的程度以及红细胞膜流动性的变化。方法 :测定2 0例 CHD患者 ( CHD组 )及 2 0例健康者 (对照组 )体内血脂、脂质过氧化物 ( L po)、氧化修饰低密度脂蛋白 ( OX-L DL)、超氧化物歧化酶 ( SOD)、红细胞膜流动性 ( M- Flu)水平。结果 :CHD患者体内低密度脂蛋白胆固醇 ( L DL-C)、载脂蛋白 B( apo B)、L po、OX- L DL 水平明显增加 ( P <0 .0 5或 <0 .0 1) ,高密度脂蛋白胆固醇 ( HDL- C)、apo A1 、SOD、M- Flu水平明显降低 (均 P <0 .0 5 ) ;结论 :CHD患者体内不仅存在着脂质代谢紊乱 ,而且还存在着明显的脂质过氧化损伤以及红细胞膜功能异常

The clinical changes of injury by lipid peroxidate and erythrocytic membrane fluidity in patients with coronary artery disease

Objective:To study the changes of injury by lipid peroxidate and erythrocytic membrane fluidity in patients with coronary artery disease.Method:We measured levels of lipid metabolism, lipid peroxidate(Lpo), oxidative modification of low density lipoprotein(OX LDL), superoxide dismutase(SOD), erythrocytic membrane fluidity (M Flu) in 20 patients with coronary artery disease and 20 normal cases.Result:The results found that levels of LDL C, apoB, Lpo, OX LDL were significantly increased and HDL C, apoA 1, SOD, M Flu were significantly decreased in patients with coronary artery disease.Conclusion:There are significant disorders of lipid metabolism and intensive injury by lipid peroxidate as well as abnormal function of erythrocytic membrane in patients with coronary artery disease.