| 急性冠脉综合征患者血浆可溶性Fas配体水平变化及其意义 |
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| 引用本文： | 杨文惠,张洪,商保军.急性冠脉综合征患者血浆可溶性Fas配体水平变化及其意义[J].心血管康复医学杂志,2011,20(2):131-134. |
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| 作者姓名： | 杨文惠 张洪 商保军 |
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| 作者单位： | 1. 河南煤化集团鹤壁煤业公司医院检验科,河南鹤壁,458000
2. 河南省人民医院血液病研究所 |
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| 摘 要： | 目的：探讨急性冠脉综合征患者血浆可溶性Fas配体（sFasL）水平的变化及其意义。方法：入选急性冠脉综合征患者50例,其中急性心肌梗塞（AMI）30例（AMI组）、不稳定型心绞痛（UAP）20例（UAP组）,另有稳定型心绞痛（SAP）患者20例为SAP组,30例健康对照者为健康对照组。采用酶联免疫吸附试验检测各组sFasL水平,并比较其结果。结果：（1）血浆sFasL水平在AMI组（100.56±30.61）pg/ml]和UAP组（51.13±23.46）pg/ml]显著高于SAP组（7.08±1.20）pg/ml]和健康对照组（6.19±1.11）pg/ml],P均〈0.01;（2）病程观察显示AMI患者经皮冠状动脉成形术后3h内血浆sFasL水平迅速下降,此后再次上升,而SAP患者则否;（3）冠状窦内sFasL水平明显高于外周血（210±40）pg/ml∶（78±21）pg/ml,P〈0.05];（4）体外研究表明FasL信使核糖核酸表达在AMI患者离体单核细胞上调,低氧可刺激离体单核细胞sFasL释放。结论：急性冠脉综合征患者sFasL水平显著升高提示Fas/FasL系统活化,可能参与急性冠脉综合征的发病过程。
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| 关 键 词： | 心肌梗塞 心绞痛 不稳定型 抗原 CD95 |
Change of plasma level of soluble Fas ligand in patients with acute coronary syndrome and its significance |
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| YANG Wen-hui,ZHANG Hong,SHANG Bao-jun.Change of plasma level of soluble Fas ligand in patients with acute coronary syndrome and its significance[J].Chinese Journal of Cardiovascular Rehabilitation Medicine,2011,20(2):131-134. |
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| Authors: | YANG Wen-hui ZHANG Hong SHANG Bao-jun |
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| Affiliation: | YANG Wen-hui,ZHANG Hong,SHANG Bao-jun//Department of Clinical Laboratory,Hospital of Coal Group of Hebi,Henan Coal and Chemical Industry Groups,Hebi,Henan,458000,China |
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| Abstract: | Objective: To explore change of plasma level of soluble Fas ligand(sFasL) in patients with acute coronary syndrome(ACS)and its significance.Methods: In 50 ACM patients,there were 30 patients with acute myocardial infarction(AMI,AMI group),20 of unstable angina pectoris(UAP,UAP group).Another there were 20 patients with stable angina pectoris(SAP,SAP group),and 30 healthy controls(healthy control group).Enzyme linked immunosorbent assay(ELISA) was used to measure sFasL levels of each group and the results we... |
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| Keywords: | Myocardial infarction Angina unstable Antigens CD95 |
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