孕晚期母亲脂质代谢紊乱对早产儿视网膜病变的影响

目的:探究孕晚期脂质代谢紊乱对早产儿视网膜病变的影响。方法:选取苏州大学附属儿童医院2017-01/2018-12期间收治的早产儿视网膜病变患儿母亲48例为观察组,同时选取同期住院的早产非视网膜病变患儿母亲48例作为对照组,比较两组研究对象孕晚期的血脂水平和脂联素水平,同时采用Pearson分析脂联素与血脂之间的相关性,Logistic回归分析早产儿视网膜病变发生的危险因素。结果:观察组研究对象孕晚期血清总胆固醇、甘油三脂、低密度脂蛋白、载脂蛋白B高于对照组产妇,而高密度脂蛋白、脂联素、载脂蛋白A1的水平低于对照组产妇。此外,Pearson分析脂联素与血脂水平存在相关性,而Logistic回归分析显示总胆固醇、甘油三脂、低密度脂蛋白、载脂蛋白B升高,高密度脂蛋白、载脂蛋白A1的水平降低为早产儿视网膜病变的危险因素。结论:孕晚期脂质代谢紊乱是早产儿视网膜病变的影响因素,可能与脂联素相关,在临床工作中应注重加强对产妇营养的指导工作,减少早产儿视网膜病变的发生。

Correlation analysis of lipid metabolism disorder of third trimester and retinopathy of prematurity in premature infants

AIM: To investigate the correlation between lipid metabolism disorder and retinopathy of prematurity(ROP)of premature infants.

METHODS: A retrospective analysis was performed on the medical data of 48 premature infants mothers who were hospitalized and diagnosed with ROP in the Department of Neonatology, Children''s Hospital of Soochow University from January 2017 to December 2018. Forty-eight hospitalized no-rop premature infants mothers were enrolled as the control group during the same period. The two groups were compared in terms of blood lipids and adiponectin level in the third trimester. Pearson correlation and Logistic regression analysis were used to analyze the correlation between adiponectin and blood lipids and risk factors of retinopathy in premature infants.

RESULTS: The total cholesterol, triglyceride, low-density lipoprotein and apolipoprotein B level in the observation group were all higher than those in the control group, while high-density lipoprotein, adiponectin and apolipoprotein A1 level were lower than those in the control group. In addition, Pearson correlation analysis showed correlation between adiponectin and blood lipid levels, while Logistic regression analysis showed increased of total cholesterol, triglycerides, low-density lipoprotein, and apolipoprotein B and decreased of high-density lipoprotein, and apolipoprotein A1 were risk factors for ROP.

CONCLUSION: Pearson test indicated positive correlation between lipid disorders of third trimester and retinopathy of premature infants, which may be related to adiponectin. In clinical work, we should focus on strengthening the guidance of maternal nutrition to reduce the incidence of ROP.