医用生物蛋白胶联合角膜缘干细胞移植在复发性翼状胬肉治疗中的应用

目的:评价医用生物蛋白胶联合角膜缘干细胞移植在复发性翼状胬肉治疗中的疗效。方法:将86例88眼复发性翼状胬肉随机分成两组,观察组46眼施行医用生物蛋白胶联合角膜缘干细胞移植治疗,对照组42眼施行翼状胬肉切除联合角膜缘干细胞移植缝线固定术。术后随访1a。结果:观察组1眼复发,复发率为2.2%,对照组6眼复发,复发率高达14.3%(P<0.05);术后1mo,观察组无异物感及移植片的水肿,对照组中10眼仍有异物感,8眼仍有移植片水肿;术后1a,观察组无睑球粘连,对照组有4眼睑球粘连。结论:医用生物蛋白胶联合角膜缘干细胞移植在复发性翼状胬肉治疗中具有手术损伤小,手术时间短,操作简单,患者无术后异物感及不用拆线,角膜创面恢复快,复发率低的特点,无睑球粘连,值得推广。

Limbal stem cell transplantation with fibrin sealant for the treatment of recurrent pterygium

AIM:To analyze the therapeutic effectiveness of the fibrin sealant with limbal stem cell transplantation in the treatment of recurrent pterygium.METHODS: Totally 88 eyes with recurrent pterygium were randomly divided into two groups: observer group of limbal stem cell transplantation with fibrin sealant and control group of string with limbal stem cell transplantation in the treatment of recurrent pterygium.RESULTS:The recurrence rate was 2.2% in observer group and 14.3% in control group, respectively(P<0.05). Postoperatively, the foreign bodies sensation and the rate of transplant edema in observer group were less than that in control group.CONCLUSION:Fibrin sealant with limbal stem cell transplantation for treating recurrent pterygium has the advantage of slight trauma, mild pain, short operative time,early recovery.It is a more effective and satisfactory surgery way. 