| 表观遗传调控与青光眼发病机制研究进展 |
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| 引用本文： | 张又嘉,陈宇虹,雷苑.表观遗传调控与青光眼发病机制研究进展[J].眼科新进展,2019,0(5):477-481. |
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| 作者姓名： | 张又嘉 陈宇虹 雷苑 |
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| 作者单位： | 200031 上海市，复旦大学附属眼耳鼻喉科医院眼科 |
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| 摘 要： | 表观遗传学主要机制包括DNA甲基化、组蛋白修饰和miRNAs等。这些机制将环境与基因相联系，在基因的特异性表达过程中发挥重要作用，影响疾病的表型。青光眼是全球第一大不可逆致盲眼病，其发病机制复杂，受遗传和环境的共同影响。本文分别对DNA甲基化、组蛋白修饰和miRNAs参与青光眼发病的机制进行综述，以期为临床诊治提供参考。
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| 关 键 词： | 青光眼 表观遗传学 DNA甲基化 组蛋白修饰 miRNAs |
Progress in epigenetics and glaucoma |
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| ZHANG You-Jia,CHEN Yu-Hong,LEI Yuan.Progress in epigenetics and glaucoma[J].Recent Advances in Ophthalmology,2019,0(5):477-481. |
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| Authors: | ZHANG You-Jia CHEN Yu-Hong LEI Yuan |
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| Affiliation: | Department of Ophthalmology，Eye and ENT Hospital of Fudan University，Shanghai 200031，China |
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| Abstract: | The main mechanisms of epigenetics include DNA methylation，histone modifications，and miRNAs.These mechanisms play important roles in specific expression of genes.Glaucoma is the top reason for blindness all over the world.It is a complex disease and is affected by both genetic and environmental factors.This review mainly discusses the relationship between epigenetics and glaucoma. |
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| Keywords: | glaucoma epigenetics DNA methylation histone modifications miRNAs |
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