子痫前期高危孕妇阿司匹林抵抗与基因多态性相关性

子痫前期是妊娠期特有的高血压疾病，近年尤其是早发型子痫前期，是孕产妇和新生儿发病和死亡的重要原因。低剂量的阿司匹林在国外已明确用于子痫前期的预防，可以减少子痫前期的发展，并降低早产和胎儿生长受限的发生率。但部分患者不能达到预期效果，存在阿司匹林抵抗。在阿司匹林预防血栓相关研究中同样存在阿司匹林抵抗现象。目前基因多态性与阿司匹林抵抗的相关性已成为研究热点。研究较多的有ABC转运蛋白家族基因、环氧合酶（COX）基因（COX-1和COX-2）、TXA2R基因、ADP受体基因、GP受体等基因多态性及其相互作用。由于其在孕妇中鲜有研究而在心脑血管疾病中研究较多，现重点从基因多态性角度阐述在心脑血管疾病中阿司匹林抵抗的可能机制，以指导阿司匹林在孕妇这类特殊人群的用药，改善妊娠结局。

Relationship between Aspirin Resistance and Gene Polymorphism in Pregnant Women with High Risk of Pre-Eclampsia

Pre-eclampsia is a hypertensive disorder specific to pregnancy that remains a significant cause of maternal and neonatal morbidity and mortality, especially early onset pre-eclampsia in recent years. Low-dose aspirin has been clearly proved effective for pre-eclampsia prevention in foreign countries and it can decrease the development of pre-eclampsia and reduce the incidence of preterm birth and fetal growth restriction. However, some patients cannot achieve the expected effect and this phenomenon is called aspirin resistance (AR). AR also exists in studies related to the prevention of thrombosis by aspirin. The study of correlation between AR and genetic polymorphism has become a hot topic, including ABC transporter family genes, COX genes (COX-1 and COX-2), TXA2R, ADP receptor, GP receptor and interaction between genes. However，it is studied rarely in pregnant woman. We will expound the possible mechanisms of AR in cardiovascular disease from the perspective of gene polymorphism, to guide the use of aspirin in pregnant women and improve the pregnancy outcome.