Interleukin-2 receptor positive cells in human decidua during the first trimester of pregnancy and their association with macrophages |
| |
Authors: | E Kovacs M Meichsner-Frauli H Ludwig |
| |
Affiliation: | 1. Seminar of Obstetrics and Gynaecology, University of Basle, Klingelbergstra?e 23, CH-4056, Basel, Switzerland
|
| |
Abstract: | Summary Maternal immune rejection of the fetus could sometimes be the cause of unexplained recurrent spontaneous abortion. Components
of the T cell-mediated immunity were investigated in the first trimester of pregnancy in women having spontaneous abortion
and compared to those with normal pregnancy having a termination on social grounds. Interleukin 2 (IL-2) had no proliferative
effect on the trophoblasts of chorionic villi and there were also no IL-2 receptors in these cells. However IL-2 receptor
positive cells were found in the decidua in 7 out of 24 women with normal pregnancy and in 12 out of 18 with spontaneous abortion.
A high density of macrophages showed an association with IL-2 receptors in both groups. There were no differences with respect
to T-cytotoxis cells and T-helper cells in cases of normal pregnancy (with and without IL-2 receptor positive cells), whereas
in women having spontaneous abortion we found lower densities of T-helper and T-cytotoxic cells in those without IL-2 receptors
than in those with IL-2 receptors. |
| |
Keywords: | IL-2 receptor Decidua Spontaneous abortion Pregnancy T-lymphocyte subpopulation |
本文献已被 SpringerLink 等数据库收录! |