Treatment of recurrent miscarriage and antiphospholipid syndrome with low-dose enoxaparin and aspirin |
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| Authors: | David Mo Sotiris Saravelos Mostafa Metwally Mike Makris TC Li |
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| Affiliation: | 1. AP-HP, Hôpital Saint-Antoine, Service de médecine interne, Inflammation–Immunopathology–Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, F-75012 Paris, France;2. Université René Descartes, Paris, France;3. APHP, Centre de reference malades auto-immunes et systemiques rares, Service de médecine interne, Hopital Cochin, Paris, France;4. Université Nantes, Nantes, France;5. Service de médecine interne, Hopital Nantes, Nantes, France;6. Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy;7. Department of Obstetrics, Gynaecology, and Pediatrics, Catholic University of Sacred Heart, Rome, Italy;8. Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Vall d''Hebrón University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain;9. Rheumatology Unit, Department of Medicine, University of Padua, Padua, Italy;10. Department of Rheumatology, University Medical Centre Ljubljana, Slovenia;11. Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, Netherlands;12. Université Paris 7, Paris, France;13. AP-HP, Unité Fonctionnelles d''Immunologie «Auto-immunité et Hypersensibilités», Hôpital Bichat-Claude Bernard, Paris, France;14. Université Paris 7, Paris, France;15. AP-HP, Service de gynécologie obstétrique, Hôpital Trousseau Paris, France;p. Université Paris 13, Bondy, France;q. AP-HP, Service de gynécologie-obstétrique, Hôpital Jean Verdier, 93140 Bondy, France |
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| Abstract: | The aim of this retrospective, observational study was to determine the impact of low-dose enoxaparin (20 mg) in conjunction with low-dose aspirin on the pregnancy outcome of women with antiphospholipid syndrome and recurrent miscarriage. The study was conducted in a tertiary referral teaching hospital. A total of 35 women with antiphospholipid syndrome were treated with low-dose enoxaparin and aspirin as soon as pregnancy was confirmed. The outcome of pregnancy was analysed. The miscarriage rate was 7/35 (20%) whereas the live birth rate was 28/35 (80%). In conclusion, low-dose (20 mg) enoxaparin in conjunction with low-dose aspirin treatment produced encouraging results. The findings in this study suggest that there is a case for randomized controlled trials to compare low-dose (20 mg) enoxaparin with higher doses. |
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