不孕症子宫内膜息肉雌激素受体和孕激素受体表达的研究

目的:探讨不孕妇女子宫内膜息肉中雌激素受体(ER)和孕激素受体(PR)的表达及意义。方法:选择2009年9月至2010年4月在广东省计划生育专科医院就诊伴发子宫内膜息肉的50例不孕妇女(EP组)作为研究组,同期就诊宫腔镜检查正常的29例不孕妇女作为对照组。采用免疫组化方法测定ER和PR在子宫内膜息肉和正常增殖期子宫内膜中的表达,同时采用化学发光法测定所有患者血清的基础性激素(血清卵泡刺激素、黄体生成素、催乳素、雌二醇和睾酮)水平,并对两组的基本情况(年龄、不孕类型、不孕原因、不孕年限及取材时间)进行比较。结果:两组基础性激素水平和基本情况的比较中,仅EP组血清雌二醇水平显著高于对照组(223.39±125.47pmol/Lvs169.96±87.46pmol/L,P=0.046),其他各项指标的比较,差异均无统计学意义(P>0.05)。ER和PR在子宫内膜息肉和增殖期子宫内膜中的表达比较,差异均无统计学意义(P=0.085,P=0.527)。结论:对于无月经改变的不孕症子宫内膜息肉,长期较高水平的雌二醇刺激可能与息肉形成有关,但子宫内膜息肉上ER、PR表达未见异常。

The Expression of Estrogen Receptor and Progesterone Receptor in Endometrial Polyps Found in Infertile Patients

Objective:To explore the expressionsy and significance of estrogen receptor(ER) and progesterone receptor(PR) in endometrial polyps found in infertile patients.Methods:From Sep,2009 to April,2010,the expressions of ER and PR were detected by immunohistochemistry in 50 infertile patients with en-dometrial polyps(EP group) and 29 infertile patients with normal uterine cavity,meanwhile the serumsex hormone level was determined by chemiluminescence.The general features of patients(including age,type of infertility,cause of infertility,time of infertility and time of specimen collection)were analyzed.Results:Serum estradiol level in EP group was significantly higher than that in control group(223.39±125.47 pmol/L vs 169.96±87.46 pmol/L,P=0.046),however,there were no differences of the other indexes between the two groups(P>0.05).The expressions of ER and PR in EP group were not statistically different compared with the control group(P=0.085,P=0.527).Conclusions:With regard to endometrial polyps without menstruation change in infertile patient,the long-term stimulation of higher estradiol level may induce endometrial polyps,but expressions of ER and PR in endometrial polyps were normal.