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Multi-omics data integration in anorexia nervosa patients before and after weight regain: A microbiome-metabolomics investigation
Authors:Alessio Maria Monteleone  Jacopo Troisi  Alessio Fasano  Riccardo Dalle Grave  Francesca Marciello  Gloria Serena  Simona Calugi  Giovanni Scala  Giulio Corrivetti  Giammarco Cascino  Palmiero Monteleone  Mario Maj
Affiliation:1. Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy;2. Theoreo srl, Via degli Ulivi 3, 84090, Montecorvino Pugliano, SA, Italy;3. European Biomedical Research Institute of Salerno (EBRIS), Via S. De Renzi, 3, 84125, Salerno, SA, Italy;4. Mucosal Immunology and Biology Research Center, Massachusetts General Hospital–Harvard Medical School, Boston, MA, USA;5. Department of Eating and Weight Disorders, Villa Garda Hospital, Garda, Verona, Italy;6. Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, Neuroscience Section, University of Salerno, Baronissi, SA, Italy;1. Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan;2. Department of Hepato-Pancreato-Biliary Surgery, National Liver Institute, Menoufia University, Egypt;3. Department of Gastroenterological and General Surgery, St. Luke''s International Hospital, Tokyo, Japan;1. Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, South China Agricultural University, Guangzhou, China;2. Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, United States;3. Université Libre de Bruxelles and Nutrition Lipid Developments SPRL, Brussels, Belgium;4. Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, United States;1. Division of Nephrology, Tagawa Municipal Hospital, Fukuoka, Japan;2. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;3. Fukuoka Renal Clinic, Fukuoka, Japan;4. Department of Internal Medicine, Fukuoka Dental College, Fukuoka, Japan;5. Department of Nephrology, Nara Medical University, Nara, Japan;1. Division of Endocrinology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil;2. Department of Social Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil;3. Division of Endocrinology, Faculdade de Medicina, Instituto de Ciências da Saúde,Universidade Federal do Pará, Belém, PA, Brazil
Abstract:
Keywords:Anorexia nervosa  Gut microbiome  Fecal metabolome  Eating disorders  Weight restoration  Multi-omics  AN"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"Anorexia Nervosa  EDE"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"Eating Disorder Examination  BSI"}  {"#name":"keyword"  "$":{"id":"kwrd0065"}  "$$":[{"#name":"text"  "_":"Brief Symptom Inventory  BMI"}  {"#name":"keyword"  "$":{"id":"kwrd0075"}  "$$":[{"#name":"text"  "_":"Body Mass Index  OTUs"}  {"#name":"keyword"  "$":{"id":"kwrd0085"}  "$$":[{"#name":"text"  "_":"Operational taxonomic units  MSA"}  {"#name":"keyword"  "$":{"id":"kwrd0095"}  "$$":[{"#name":"text"  "_":"Multiple sequence alignment  LEfSe"}  {"#name":"keyword"  "$":{"id":"kwrd0105"}  "$$":[{"#name":"text"  "_":"Linear discriminant effect size  LDA"}  {"#name":"keyword"  "$":{"id":"kwrd0115"}  "$$":[{"#name":"text"  "_":"Linear discriminant analysis  SCFA"}  {"#name":"keyword"  "$":{"id":"kwrd0125"}  "$$":[{"#name":"text"  "_":"Small chain fatty acids  BCFA"}  {"#name":"keyword"  "$":{"id":"kwrd0135"}  "$$":[{"#name":"text"  "_":"branched-chain fatty acids  DSM-5"}  {"#name":"keyword"  "$":{"id":"kwrd0145"}  "$$":[{"#name":"text"  "_":"Diagnostic and Statistical Manual for Mental Disorders-5th edition
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