番茄红素对2型糖尿病患者慢性炎症因子的影响

目的观察番茄红素(Lyc)对2型糖尿病(T2DM)患者血清炎症因子水平的作用。方法选取T2DM患者130例随机分为:A组(干预组)64例,给予Lyc胶囊30mg/d;B组(对照组)66例,不服用Lyc但给予安慰剂;另取年龄和性别匹配的62名健康志愿者入C组(健康组)。A、B两组患者均采集入组时和干预后3个月的空腹血清,C组采集一次空腹血清,于-80℃冰箱保存待测。监测餐前、餐后2 h末梢血糖,测定生化指标,用ELISA法测定血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平及外周血单核细胞胞核蛋白中NF-κB水平。结果两组患者相关炎症因子基线水平明显高于C组(P<0.05);干预治疗后,两组患者空腹血糖、餐后血糖均显著降低(P<0.05)。干预后3个月A组IL-6、TNF-α、hs-CRP、NF-κB水平均显著降低(P<0.05)。B组上述炎症因子水平变化差异无统计学意义(P>0.05)。结论 T2DM患者炎症因子水平明显高于健康人群,Lyc干预可显著降低其部分炎症因子水平。

EFFECTS OF LYCOPENE ON INFLAMATORY FACTORS IN PATIENTS WITH TYPE 2 DIABETES

Objective To evaluate the effect of lycopene(Lyc) on serum inflammatory factors in patients with type 2 diabetes mellitus(T2DM).Methods One hundred and thirty T2DM patients who had no major vascular complications were recruited and randomly divided into two groups:Lyc treated group(A group,n=64) and control group(B group,n=66).Sixty-two healthy subjects were enrolled as normal control(C group).In A group,the patients were given orally Lyc 30 mg twice daily for 3 mo.In B group,the patients were given the placebo for 3 mo.Their biochemical indicators and inflammatory factors were measured before and after treatment.Results The baseline levels of inflammatory factors in the diabetic patients were significantly higher than normal control(P<0.05).The fasting blood glucose and postprandial blood glucose were significantly decreased after intervention in the two diabetic groups(P<0.05).Repeated measurement ANOVA analysis showed that after 3 mo intervention,IL-6,TNF-α,hs-CRP and NF-κB decreased significantly in A group than in B group(P<0.05),but the trend in B group was not changed(P>0.05).Conclusion The levels of inflammatory factors were elevated in patients with T2DM,which could be reduced by Lyc.