乙型肝炎疫苗阻断新婚夫妇HBV传播的效果观察

61例婚前体检对方为HBsAg(+)或HBsAg和HBeAg(+)的易感配偶,随机单盲分成两组于婚前接种乙肝疫苗或安慰剂。结果6个月后抗-HBs阳转率分别为93.33%(28/30)和6.45%(2/31),差异显著(P<0.01),结婚暴露6~12个月HBV感染率分别为6.67%(2/30)和61.29%(19/31),P<0.01,其保护率达89.12%,95%可信限为74.24~100.00%。表明乙肝疫苗接种易感新婚夫妇的血清免疫应答和阻断HBV传播的流行病学效果可靠。这对个人、家庭和后代是有益的。

Observation on Prevention of Hepatitis B Virus Transmission between Newly-married Couples by HBsAg Vaccing

Sixty-one young men and women, whose finances were found to be HBsAg (+) or partly HBeAg (+), had undergone medical examination before marriage. They were divided into two groups and given HBV vaccine or placebo before marriage. Six months later, the seroconversion rates of anti-HBs in these two groups were 93.33% (28/30) and 6.45% (2/31), respectively. The difference was statistically significant (P less than 0.01). Six-twelve months after marriage, the HBsAg positive rates were 6.67% (2/30) and 61.29% (9/31), respectively. This difference was highly significant (P less than 0.001). The protective rate of HB vaccine reached 89.12%. The results suggested that it is important to vaccinate the susceptible persons to be married to enhance their immunity against HBV, especially when the finances were found to be HBsAg positive (+) before marriage.